Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell Lymphomagenesis
Gu X, Booth C, Liu Z, Strout M. Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell Lymphomagenesis. Blood 2013, 122: 1247. DOI: 10.1182/blood.v122.21.1247.1247.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaB-cell lymphomaMsh2-/- miceCell lymphomaB cellsChromosome abnormalitiesLarge B-cell lymphomaShorter median timePre-B-cell tumorsSquamous cell carcinomaFollicular B-cell lymphomaT-cell lymphomaHuman diffuse large B-cell lymphomaGerminal center B cellsMSH2-dependent mismatch repairPathogenesis of GCSingle-deficient miceDevelopment of DLBCLNet protective effectDevelopment of tumorsClonal mutationsPre-B cell lymphomaGC B cellsMedian survivalMedian timeRelated F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
Chiorazzi M, Rui L, Yang Y, Ceribelli M, Tishbi N, Maurer CW, Ranuncolo SM, Zhao H, Xu W, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Shaham S, Staudt LM. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3943-3948. PMID: 23431138, PMCID: PMC3593917, DOI: 10.1073/pnas.1217271110.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisBase SequenceCaenorhabditis elegansCaenorhabditis elegans ProteinsCaspasesCell Line, TumorEnzyme ActivationF-Box ProteinsHEK293 CellsHumansLymphomaLymphoma, Large B-Cell, DiffuseMolecular Sequence DataMutation, MissenseProto-Oncogene Proteins c-bcl-2Repressor ProteinsRNA, MessengerRNA, NeoplasmSequence Homology, Amino AcidConceptsCED-9Cell deathCaenorhabditis elegansDRE-1Caspase CED-3Control cell deathApoptotic cell deathRegulators of apoptosisEGL-1CED-3Cell fateHuman diffuse large B-cell lymphomaHuman proteinsCaspase activationFBXO10BCL2 proteinElegansProteinHuman malignanciesHuman lymphomasAlternative mechanismApoptosisActivationBH3Regulator
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply