2022
Transient receptor potential melastatin 7 and their modulators
Cheng X, Li S, Chen Y, Zhao Y, Hu W, Lu C, Zhou R. Transient receptor potential melastatin 7 and their modulators. European Journal Of Pharmacology 2022, 931: 175180. PMID: 35940237, DOI: 10.1016/j.ejphar.2022.175180.Peer-Reviewed Original ResearchConceptsUnique domain structureCation channelsRegulation of TRPM7Transient receptor potential melastatin 7Molecular signaling pathwaysProtein kinaseFunction of TRPM7Regulatory mechanismsPhysiological processesInternal regulatory mechanismsSignaling pathwaysExogenous regulationNonselective cation channelsCell membraneTRPM7Development of tumorsCell proliferationTRPM7 activityPhenotypic transformationRegulationPharmacological compoundsImportant targetIntracellular MgTRPM7 expressionTissue fibrosis
2013
Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell Lymphomagenesis
Gu X, Booth C, Liu Z, Strout M. Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell Lymphomagenesis. Blood 2013, 122: 1247. DOI: 10.1182/blood.v122.21.1247.1247.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaB-cell lymphomaMsh2-/- miceCell lymphomaB cellsChromosome abnormalitiesLarge B-cell lymphomaShorter median timePre-B-cell tumorsSquamous cell carcinomaFollicular B-cell lymphomaT-cell lymphomaHuman diffuse large B-cell lymphomaGerminal center B cellsMSH2-dependent mismatch repairPathogenesis of GCSingle-deficient miceDevelopment of DLBCLNet protective effectDevelopment of tumorsClonal mutationsPre-B cell lymphomaGC B cellsMedian survivalMedian time
2012
[Experimental study of inhibition of tumor cell proliferation by a novel gene SPATA12].
Liu Z, Lin Y, Liu X, Yu W, Zhang Y, Li D. [Experimental study of inhibition of tumor cell proliferation by a novel gene SPATA12]. Journal Of Central South University Medical Sciences 2012, 37: 222-7. PMID: 22561491, DOI: 10.3969/j.issn.1672-7347.2012.03.002.Peer-Reviewed Original ResearchConceptsTumor cell proliferationTesticular tumorsCell proliferationColony formationReverse transcription-polymerase chainSitu hybridization analysisTranscription-polymerase chainNormal adult testisDevelopment of tumorsDiphenyl tetrazolium bromideCell cycle genesTissue microarrayCyclin D1MRNA expressionTumor cellsInhibitory roleCyclin A1 geneCyclin E1RT-PCRTumorsDimethylthiazol-2MTT assayTetrazolium bromideCyclin B1Expression levels
2011
Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs
Rockwell S, Liu Y, Mayne ST, Redlich CA. Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs. Experimental Biology And Medicine 2011, 236: 1173-1179. PMID: 21844122, PMCID: PMC3207150, DOI: 10.1258/ebm.2011.011082.Peer-Reviewed Original ResearchConceptsWhole lung irradiationSubclinical vitaminSpontaneous lung metastasesLung metastasesLung tumorsVitamin ALung irradiationTumor cellsLow vitaminDeficient dietSubcutaneous tumorsPossible modifiable risk factorsSeverity of pneumonitisModifiable risk factorsRadiation-induced pneumonitisEnhancement of metastasisImpact of vitaminDose-dependent increaseLevels of retinolGrowth of tumorsDevelopment of tumorsDose-response curveLung injuryLung levelsPrimary cancer
2002
Mutations in the VHL gene in sporadic apparently congenital polycythemia
Pastore Y, Jelinek J, Ang S, Guan Y, Liu E, Jedlickova K, Krishnamurti L, Prchal J. Mutations in the VHL gene in sporadic apparently congenital polycythemia. Blood 2002, 101: 1591-1595. PMID: 12393546, DOI: 10.1182/blood-2002-06-1843.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArginineAspartic AcidBase SequenceChildChild, PreschoolDNA Mutational AnalysisErythroid Precursor CellsErythropoietinFemaleHeterozygoteHomozygoteHumansLeucineLigasesMaleMutationPedigreePolycythemiaSequence Analysis, DNATryptophanTumor Suppressor ProteinsTyrosineUbiquitin-Protein LigasesValineVon Hippel-Lindau Tumor Suppressor ProteinConceptsVon Hippel-LindauVHL geneTumor suppressor von Hippel-LindauPolycythemic disordersDownstream target genesVHL mutationsHypoxia-sensing pathwayVHL functionHypoxia-inducible factor-1alphaProteosomal degradationTarget genesErythroid cellsGermline VHL mutationsCongenital polycythemiaChuvash polycythemiaVHL syndromeGenesHIF-1alphaDevelopment of tumorsFactor-1alphaElevated serum Epo levelsMutationsEPO productionAutosomal dominant disorderPathway
1991
Cutaneous T-cell lymphoma
Braverman I. Cutaneous T-cell lymphoma. Current Problems In Dermatology 1991, 3: 184-227. DOI: 10.1016/1040-0486(91)90005-o.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaT-cell lymphomaHelper T cellsSézary syndromeMycosis fungoidesStage diseaseNodal involvementEffective therapyT cellsCharacteristic cutaneous findingsMycosis fungoides variantEarly-stage diseaseLate-stage diseaseChronic inflammatory processTopical nitrogen mustardDevelopment of tumorsExtracorporeal photophoresisSustained remissionVisceral involvementCutaneous findingsStaging procedureClinical featuresCutaneous malignanciesInflammatory processChronic stimulation
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