2014
FKBP5 variation is associated with the acute and chronic effects of nicotine
Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine. The Pharmacogenomics Journal 2014, 15: 340-346. PMID: 25532758, PMCID: PMC4599366, DOI: 10.1038/tpj.2014.76.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanBlood PressureDiagnostic and Statistical Manual of Mental DisordersGene FrequencyGenotypeHeart RateHumansHydrocortisoneInjections, IntravenousNicotineNicotinic AgonistsRNARNA, MessengerSmokingSubstance Withdrawal SyndromeTacrolimus Binding ProteinsWhite PeopleConceptsNicotine withdrawalFKBP5 mRNA expressionNegative drug effectsHeart rateIndependent cohortDrug effectsMRNA expressionMinor alleleChronic behavioral effectsEffects of nicotineStress hormone regulationLower cortisol levelsWarrants further investigationSevere nicotine withdrawalCurrent smokersBlood pressureHeavy smokersQuit attemptsHR responseSmoking behaviorCortisol responseCortisol levelsLower subjective ratingsSmokersChronic effects
2006
Autonomic Nervous System Interaction With the Cardiovascular System During Exercise
Freeman JV, Dewey FE, Hadley DM, Myers J, Froelicher VF. Autonomic Nervous System Interaction With the Cardiovascular System During Exercise. Progress In Cardiovascular Diseases 2006, 48: 342-362. PMID: 16627049, DOI: 10.1016/j.pcad.2005.11.003.Peer-Reviewed Original ResearchConceptsExercise testHR variabilityHR recoveryCardiovascular systemSudden cardiac deathAutonomic nervous system interactionsSignificant prognostic informationAutonomic nervous systemHeart rate responseStandard exercise testNervous system interactionsConsiderable recent evidenceExercise testingCardiac deathPrognostic significancePrognostic valuePrognostic informationCardiovascular patientsExercise measurementsHR responseNervous systemRate responseRecent evidenceExerciseFuture findings
2002
Association of heart rate response with scan and left ventricular function on adenosine myocardial perfusion imaging
Vashist A, Heller E, Blum S, Brown E, Bhalodkar N. Association of heart rate response with scan and left ventricular function on adenosine myocardial perfusion imaging. The American Journal Of Cardiology 2002, 89: 174-177. PMID: 11792338, DOI: 10.1016/s0002-9149(01)02196-8.Peer-Reviewed Original ResearchConceptsBeats/minMyocardial perfusion imagingEjection fractionAbnormal scansAdenosine myocardial perfusionHeart rate responseVentricular functionScan groupMyocardial perfusionAdenosine myocardial perfusion imagingAbnormal scan groupAdenosine stress testNormal scan groupRate responseNormal ejection fractionLV ejection fractionAverage HRSingle photon emissionConsecutive patientsMean ageNormal scansPeak HRReversible defectsGroup 2HR response
1989
Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea
Hanly P, George C, Millar T, Kryger M. Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea. CHEST Journal 1989, 95: 735-739. PMID: 2924602, DOI: 10.1378/chest.95.4.735.Peer-Reviewed Original ResearchConceptsVoluntary respiratory maneuversObstructive sleep apneaHR responseSleep apneaRespiratory maneuversMueller maneuverOxygen saturationVagal toneAbsence of hypoxemiaArterial oxygen saturationHeart rate responseObstructive apneaMouth pressureApneaHR changesMale subjectsRate responseBreath holdSimilar durationValsalvaSignificant differencesSignificant correlationOSASMajor determinantWakefulness
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