2017
Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation
Tahvildari M, Emami-Naeini P, Omoto M, Mashaghi A, Chauhan S, Dana R. Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation. Scientific Reports 2017, 7: 971. PMID: 28428556, PMCID: PMC5430534, DOI: 10.1038/s41598-017-01065-z.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHigh-risk corneal transplantationCorneal transplantationDonor corneasGraft survivalT cellsMouse model of corneal transplantationTissue-resident antigen-presenting cellsModel of corneal transplantationTolerogenic antigen-presenting cellsGraft bedImmature antigen-presenting cellsMigrate to lymphoid tissuesCorneal allograft recipientsCorneal allograft survivalDonor corneal stromaInflamed graft bedsDonor corneal tissueTransforming growth factor-b1Effector T cellsCD4+ cellsHost T cellsPromote graft survivalSaline-injected controlsGraft infiltration
2016
Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 AxisDetermining Dendritic Cell Trafficking
Hua J, Stevenson W, Dohlman T, Inomata T, Tahvildari M, Calcagno N, Pirmadjid N, Sadrai Z, Chauhan S, Dana R. Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 AxisDetermining Dendritic Cell Trafficking. Investigative Ophthalmology & Visual Science 2016, 57: 1457-1467. PMID: 27031839, PMCID: PMC4819620, DOI: 10.1167/iovs.15-17551.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCells, CulturedChemokine CCL19Chemokine CCL21Corneal TransplantationDendritic CellsDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFlow CytometryGene Expression RegulationGraft SurvivalMaleMiceMice, Inbred BALB CMice, Inbred C57BLReal-Time Polymerase Chain ReactionReceptors, CCR7RNAConceptsDraining Lymph NodesAntigen-presenting cellsInflamed graft bedsBone marrow-derived dendritic cellsDendritic cellsDendritic cell traffickingGraft bedSite inflammationMouse model of corneal transplantationModel of corneal transplantationCell traffickingMature bone marrow-derived dendritic cellsMarrow-derived dendritic cellsCD11c+ dendritic cellsMature DC migrationCorneal transplantationDonor corneasGraft survivalLymph nodesCCR7 ligandsLigands CCL19DC migrationMouse modelTranswell migration assayFlow cytometry
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply