2024
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Zhang X, Song B, Carlino M, Li G, Ferchen K, Chen M, Thompson E, Kain B, Schnell D, Thakkar K, Kouril M, Jin K, Hay S, Sen S, Bernardicius D, Ma S, Bennett S, Croteau J, Salvatori O, Lye M, Gillen A, Jordan C, Singh H, Krause D, Salomonis N, Grimes H. An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors. Nature Immunology 2024, 25: 703-715. PMID: 38514887, PMCID: PMC11003869, DOI: 10.1038/s41590-024-01782-4.Peer-Reviewed Original ResearchSurface markersLeukemia stem cell populationHematopoietic progenitor compartmentBone marrow cellsHuman bone marrow cellsHuman hematopoietic progenitorsCell surface markersStem cell populationCITE-seqClinical responseHematopoietic progenitorsMarrow cellsProgenitor compartmentCellular Indexing of TranscriptomesTransitional cellsCell populationsProgenitor analysisCellular indicesMultimodal approachGenomics programsProgenitor stateTranscriptome profilingSurface proteinsProgenitorsCell states
2007
Donor‐Derived Human Bone Marrow Cells Contribute to Solid Organ Cancers Developing After Bone Marrow Transplantation
Avital I, Moreira A, Klimstra D, Leversha M, Papadopoulos E, Brennan M, Downey R. Donor‐Derived Human Bone Marrow Cells Contribute to Solid Organ Cancers Developing After Bone Marrow Transplantation. Stem Cells 2007, 25: 2903-2909. PMID: 17690178, DOI: 10.1634/stemcells.2007-0409.Peer-Reviewed Original ResearchConceptsAllogeneic bone marrow transplantationSolid organ cancersBone marrow-derived stem cellsBone marrow transplantationMarrow-derived stem cellsOrgan cancersMalignant cellsMarrow transplantationStem cellsCells of donor originTotal body irradiationAberrant stem cell differentiationBone marrow cellsBone marrow stem cellsHuman bone marrow cellsMarrow stem cellsBody irradiationEpithelial malignanciesTumor cellularityDonor originMale patientsMarrow cellsHuman bone marrow-derived stem cellsHuman neoplasiaCancer carcinogenesis
2003
Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice
Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, Krause DS. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Experimental Hematology 2003, 31: 413-420. PMID: 12763140, DOI: 10.1016/s0301-472x(03)00042-0.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsNOD/SCID miceMesenchymal stem cellsMSC cotransplantationTransplant recipientsSCID miceCotransplantation of MSCsHematopoietic stem cellsHuman peripheral blood stem cellsStem cellsAllogeneic transplant recipientsTransplantation of CD34Autologous transplant recipientsHuman mesenchymal stem cellsBlood stem cellsHuman cell engraftmentMarrow-derived stromal cellsBone marrow cellsPlatelet engraftmentHuman bone marrow cellsHuman hematopoietic stem cellsCotransplantationBone marrowMegakaryocytic engraftmentB lymphocytes
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