2017
Tumor-associated macrophages, nanomedicine and imaging: the axis of success in the future of cancer immunotherapy
Zanganeh S, Spitler R, Hutter G, Ho J, Pauliah M, Mahmoudi M. Tumor-associated macrophages, nanomedicine and imaging: the axis of success in the future of cancer immunotherapy. Immunotherapy 2017, 9: 819-835. PMID: 28877626, DOI: 10.2217/imt-2017-0041.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesTumor microenvironmentCancer immunotherapyTargeting of tumor-associated macrophagesTAM modulationImmune tumor microenvironmentIndividualized cancer therapyTarget specific cell typesInfluence tumor microenvironmentImprove treatment efficacyTheranostic probesModulate immune functionNucleic acid deliveryMultimodal imaging strategyTumor responseImmunotherapeutic interventionsSpecific cell typesSolid tumorsImmune cellsTranslational research approachTreatment optionsClinical trialsImproved biomarkersCancer therapyImmunotherapy
2013
Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals
Sandiego CM, Jin X, Mulnix T, Fowles K, Labaree D, Ropchan J, Huang Y, Cosgrove K, Castner SA, Williams GV, Wells L, Rabiner EA, Carson RE. Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals. Journal Of Nuclear Medicine 2013, 54: 1962-1968. PMID: 24115528, PMCID: PMC3857935, DOI: 10.2967/jnumed.113.122077.Peer-Reviewed Original ResearchConceptsHead restraintAwake nonhuman primatesAwake conditionNonhuman primatesInfrared cameraAnesthetized conditionMechanical devicesAminobutyric acid type AIsoflurane-anesthetized conditionIntravenous catheter insertionClose agreementIsoflurane-anesthetized monkeysSmall animal PET scannerTranslational research approachAnimal PET scannerFlumazenil administrationCatheter insertionNHP studiesAnesthetized monkeysConstant infusion methodPET scansPET scannerAnesthetized animalsCortisol levelsCustom chair
2011
Advancing drug discovery for schizophrenia
Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Saw A, Caron MG, George SR, Allen JA, Solis M. Advancing drug discovery for schizophrenia. Annals Of The New York Academy Of Sciences 2011, 1236: 30-43. PMID: 22032400, PMCID: PMC3787879, DOI: 10.1111/j.1749-6632.2011.06216.x.Peer-Reviewed Original Research
2008
Practitioner Review: Adolescent alcohol use disorders: assessment and treatment issues
Perepletchikova F, Krystal JH, Kaufman J. Practitioner Review: Adolescent alcohol use disorders: assessment and treatment issues. Journal Of Child Psychology And Psychiatry 2008, 49: 1131-1154. PMID: 19017028, PMCID: PMC4113213, DOI: 10.1111/j.1469-7610.2008.01934.x.Peer-Reviewed Original ResearchConceptsAdolescent alcohol use disordersAlcohol use disorderUse disordersMultidimensional Family TherapyCognitive behavioral therapyBurgeoning of researchSubstance use disordersPaucity of researchBehavioral therapyTrauma experiencesFamily therapyEmpirical supportPharmacological interventionsClinical interventionsIntervention strategiesFirm treatment recommendationsAppropriate clinical interventionsTreatment issuesAdolescentsTranslational research approachDisordersNovel intervention strategiesRandomized studyInterventionSignificant morbidity
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