Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals
Sandiego CM, Jin X, Mulnix T, Fowles K, Labaree D, Ropchan J, Huang Y, Cosgrove K, Castner SA, Williams GV, Wells L, Rabiner EA, Carson RE. Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals. Journal Of Nuclear Medicine 2013, 54: 1962-1968. PMID: 24115528, PMCID: PMC3857935, DOI: 10.2967/jnumed.113.122077.Peer-Reviewed Original ResearchConceptsHead restraintAwake nonhuman primatesAwake conditionNonhuman primatesInfrared cameraAnesthetized conditionMechanical devicesAminobutyric acid type AIsoflurane-anesthetized conditionIntravenous catheter insertionClose agreementIsoflurane-anesthetized monkeysSmall animal PET scannerTranslational research approachAnimal PET scannerFlumazenil administrationCatheter insertionNHP studiesAnesthetized monkeysConstant infusion methodPET scansPET scannerAnesthetized animalsCortisol levelsCustom chair
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