2025
Soil‐Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species‐Specific Effects Within the Old Friends Hypothesis
Cepon‐Robins T, Gildner T, Urlacher S, Liebert M, Madimenos F, Bribiescas R, Eick G, Harrington C, Sugiyama L, Snodgrass J. Soil‐Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species‐Specific Effects Within the Old Friends Hypothesis. American Journal Of Human Biology 2025, 37: e70076. PMID: 40444920, PMCID: PMC12175971, DOI: 10.1002/ajhb.70076.Peer-Reviewed Original ResearchConceptsSystemic inflammationImmune biomarkersIL-6Infection statusSpecies-specific relationshipsOld Friends hypothesesSpecies-specific effectsExacerbated systemic inflammationSoil-Transmitted HelminthsFinger-prick blood samplesLevels of CRPLow CRP levelsHelminth speciesCoinfected participantsAmazonian EcuadorHigh IgECRP levelsUninfected participants
2024
Investigating Environmental Determinants of Hookworm Transmission using GPS Tracking and Metagenomics Technologies
Sumboh J, Agyenkwa-Mawuli K, Schwinger E, Donkor I, Akorli J, Dwomoh D, Ashong Y, Osabutey D, Ababio F, Nusbaum O, Humphries D, Cappello M, Koram K, Kwofie S, Wilson M. Investigating Environmental Determinants of Hookworm Transmission using GPS Tracking and Metagenomics Technologies. American Journal Of Tropical Medicine And Hygiene 2024, 112: 561-570. PMID: 39813691, PMCID: PMC11884298, DOI: 10.4269/ajtmh.24-0384.Peer-Reviewed Original ResearchConceptsEffective cation exchange capacityCation exchange capacitySandy-loam soilDominant helminth speciesSoil samplesClay contentSoil parametersExchange capacityHelminth larvaeAnalysis of DNA sequencesGPS trackingSoilParastrongyloides trichosuriAssociated with exposureLarvaeChemical propertiesPotential sourcesMovement dataSpeciesPredominant speciesHelminth speciesLarval countsMetagenomic technologiesDNA sequencesMetagenomic analysis
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