2025
Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use
Davis C, Jinwala Z, Justice A, Rentsch C, Kranzler H. Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use. Alcohol Clinical And Experimental Research 2025, 49: 1197-1205. PMID: 40322892, PMCID: PMC12174493, DOI: 10.1111/acer.70069.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMillion Veteran ProgramGenome-wide significancePolygenic scoresAlcohol consumptionAssociation studiesAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresGenome-wide association study samplesPhenome-wide association studyAlcohol useElectronic health recordsMeta-analysisGWAS Meta-AnalysisMulti-ancestry genome-wide association studyTopiramate's effectsAlcohol use disorder diagnosisCross-ancestry meta-analysisFrequency of alcohol useCandidate gene studiesHeavy alcohol useHealth recordsVeteran ProgramAlcohol-related liver diseaseCross-ancestryTreatment response
2024
47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS
Friligkou E, Løkhammer S, Mendoza B, Shen J, He J, Deiana G, Zanoaga M, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee D, Pathak G, Polimanti R. 47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS. European Neuropsychopharmacology 2024, 87: 74-75. DOI: 10.1016/j.euroneuro.2024.08.161.Peer-Reviewed Original ResearchMillion Veteran ProgramPolygenic riskLatent causal variable methodMulti-tissue transcriptome-wide association studyUK Biobank (UKBGenetic correlationsTranscriptome-wide association studyAnxiety disordersGenomic structural equation modelingLD score regressionLocal genetic correlationGWAS Meta-AnalysisProteome-wide analysisGenetics of anxietyAssociated with anxietyMulti-omics informationS-MultiXcanVeteran ProgramLD scoresAncestry-specificTranscriptome-wideAncestral populationsCross-ancestryGene discoveryAssociation studies
2022
Genome-wide association meta-analysis identifies 29 new acne susceptibility loci
Mitchell B, Saklatvala J, Dand N, Hagenbeek F, Li X, Min J, Thomas L, Bartels M, Jan Hottenga J, Lupton M, Boomsma D, Dong X, Hveem K, Løset M, Martin N, Barker J, Han J, Smith C, Rentería M, Simpson M. Genome-wide association meta-analysis identifies 29 new acne susceptibility loci. Nature Communications 2022, 13: 702. PMID: 35132056, PMCID: PMC8821634, DOI: 10.1038/s41467-022-28252-5.Peer-Reviewed Original ResearchConceptsRisk lociSusceptibility lociGenome-wide significant lociGenome-wide association meta-analysisIdentified risk lociEuropean ancestry cohortsGWAS Meta-AnalysisAssociation meta-analysisHeritable skin disordersAncestry cohortsSignificant lociFine-mappingPolygenic risk scoresSeverely inflamed lesionsLociGenetic aetiologyPsychiatric traitsLong-term psychosocial consequencesMeta-analysisSkin disordersEQTLIndependent cohortGWASPsychosocial consequencesHormone-sensitive cancers
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