2023
Are opioids effective analgesics and is physiological opioid dependence benign? Revising current assumptions to effectively manage long‐term opioid therapy and its deprescribing
Manhapra A, MacLean R, Rosenheck R, Becker W. Are opioids effective analgesics and is physiological opioid dependence benign? Revising current assumptions to effectively manage long‐term opioid therapy and its deprescribing. British Journal Of Clinical Pharmacology 2023, 90: 2962-2976. PMID: 37990580, PMCID: PMC11563311, DOI: 10.1111/bcp.15972.Peer-Reviewed Original ResearchLong-term opioid therapyOpioid therapyFunctional gainsChronic pain syndromeMaximum functional recoveryOngoing opioid crisisParadoxical worseningAnalgesic benefitAnalgesic therapyPain reliefPain syndromeEffective analgesicMost patientsAntinociceptive effectAntinociceptive systemChronic painFunctional recoveryOpioid actionOpioid dependenceMedical instabilityFunctional improvementPlacebo effectClinical principlesOpioid crisisTherapeutic inductionRegional Analgesia for Cesarean Delivery: A Narrative Review Toward Enhancing Outcomes in Parturients
Silverman M, Zwolinski N, Wang E, Lockwood N, Ancuta M, Jin E, Li J. Regional Analgesia for Cesarean Delivery: A Narrative Review Toward Enhancing Outcomes in Parturients. Journal Of Pain Research 2023, 16: 3807-3835. PMID: 38026463, PMCID: PMC10644837, DOI: 10.2147/jpr.s428332.Peer-Reviewed Original ResearchPeripheral nerve blocksRegional anesthetic techniquesPost-cesarean section analgesiaPost-cesarean analgesiaNeuraxial morphineNerve blockAnesthetic techniquePlane blockAnalgesic benefitCesarean sectionPost-cesarean pain managementPost-operative opioid consumptionTransversus abdominis plane blockErector spinae plane blockLow transverse cesarean sectionPeripheral nerve block techniquesLiterature searchLocal anesthetic injectionGold standardNerve block techniqueBetter analgesiaIntrathecal morphineOpioid consumptionPostoperative analgesiaNeuraxial opioidsKetamine
Shergill S, Vadivelu N. Ketamine. 2023, 195-205. DOI: 10.1007/978-3-031-21291-8_13.Peer-Reviewed Original ResearchPost-operative pain controlPost-operative analgesiaSympathetic nervous systemMaintenance of anesthesiaMultiple surgical proceduresMu-opioid receptorsNMDA receptor antagonismComplete anestheticERAS protocolOperative analgesiaAnalgesic benefitPain controlPulmonary diseaseSeptic shockChronic painReceptor antagonismSubanesthetic dosesOpioid receptorsPotent analgesicSurgical proceduresHepatic enzymesNervous systemPartial agonistKetaminePatients
2020
Nitrous oxide analgesia for external cephalic version: A randomized controlled trial
Straube LE, Fardelmann KL, Penwarden AA, Chen F, Harker E, Redmon BF, Li Q, Strauss R, Smith KA. Nitrous oxide analgesia for external cephalic version: A randomized controlled trial. Journal Of Clinical Anesthesia 2020, 68: 110073. PMID: 33017784, DOI: 10.1016/j.jclinane.2020.110073.Peer-Reviewed Original ResearchConceptsExternal cephalic versionNitrous oxide analgesiaCephalic versionNitrous oxide groupOxygen placeboBreech presentationPatient satisfactionDouble-blinded randomized placebo-controlled trialRandomized placebo-controlled trialAnesthesiology physical status IRoutine useIntra-procedural painMean pain scorePlacebo-controlled trialPhysical status IYears of ageMinimal side effectsNitrous oxide/50Analgesic benefitPain scoresSecondary outcomesSingleton pregnanciesStatus IPrimary outcomeNeuraxial anesthesia
2018
The role of sciatic nerve block to complement femoral nerve block in total knee arthroplasty: a meta-analysis of randomized controlled trials
Zorrilla-Vaca A, Li J. The role of sciatic nerve block to complement femoral nerve block in total knee arthroplasty: a meta-analysis of randomized controlled trials. Journal Of Anesthesia 2018, 32: 341-350. PMID: 29520522, DOI: 10.1007/s00540-018-2480-1.Peer-Reviewed Original ResearchConceptsSciatic nerve blockTotal knee arthroplastyContinuous sciatic nerve blockPatient-controlled analgesiaNerve blockPain scoresStandardized mean differenceOpioid consumptionKnee arthroplastySingle-injection sciatic nerve blockControl groupSciatic-femoral nerve blockIntravenous opioid consumptionPostoperative analgesic benefitsPostoperative opioid consumptionIncidence of nauseaFemoral nerve blockLess pain scoresRandom-effects modelSystematic literature searchEvidence-based supportAnalgesic benefitHospital stayAcute painRandomized trials
2015
Combined Use of Opioids and Antidepressants in the Treatment of Pain: A Review of Veterans Health Administration Data for Patients with Pain Both With and Without Co-morbid Depression
Sellinger JJ, Sofuoglu M, Kerns RD, Rosenheck RA. Combined Use of Opioids and Antidepressants in the Treatment of Pain: A Review of Veterans Health Administration Data for Patients with Pain Both With and Without Co-morbid Depression. Psychiatric Quarterly 2015, 87: 585-593. PMID: 26646578, DOI: 10.1007/s11126-015-9411-1.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationMusculoskeletal painAntidepressant useVeterans Health Administration dataAnnual opioid prescriptionsNational VHA databasesUse of antidepressantsCo-morbid depressionTreatment of painHealth Administration dataMajor depressive disorderNon-depressed groupOpioid therapyAnalgesic benefitOpioid prescribingOpioid prescriptionsPrescribing patternsOpioid useVHA databasesFiscal year 2012Depressive disorderDepression diagnosisPainAntidepressantsOpioids
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