2013
Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana
Barry O, Powell J, Renner L, Bonney EY, Prin M, Ampofo W, Kusah J, Goka B, Sagoe K, Shabanova V, Paintsil E. Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana. BMC Infectious Diseases 2013, 13: 476. PMID: 24119088, PMCID: PMC3852953, DOI: 10.1186/1471-2334-13-476.Peer-Reviewed Original ResearchConceptsPediatric HIV clinicResource-limited countriesViral loadDrug-resistant mutationsVirologic failureHIV clinicFirst-line antiretroviral therapyHIV viral load monitoringCohort of HIVFirst-line ARTFirst-line regimenGenotypic resistance testingHIV viral loadInitiation of therapyType of regimenViral load monitoringSeverity of illnessViral load testingVirologic treatment failurePrimary care giversAntiretroviral therapyART regimensCD4 countTreatment failureWHO criteria
2012
Track B Clinical Science
Kyrychenko T, Dubynska G, Koval T, Kaidashev I, Korshenko V, Rono K, Kibuuka H, Maganga L, Kosgei J, Sekiziyivu A, Sanga E, Ngetich E, Valenzuela A, Michael N, Robb M, Markowitz M, Evering T, Figueroa A, Rodriguez K, La Mar M, Garmon D, Sahi V, Mohri H, Asher A, Santos G, Dokubo E, Martin J, Deeks S, Tobler L, Busch M, Hunt P, Page K, Weber R, Smith C, Group D, Mannheimer S, Wang L, Tieu H, del Rio C, Buchbinder S, Wilton L, Glick S, Cummings V, Mayer K, Hutchinson A, Sansom S, Farnham P, Davis R, Dzoro S, Moyo S, Gaseitsiwe S, Musonda R, Novitsky V, Essex M, Ouma K, Basavaraju S, Okonji J, Williamson J, Mills L, Zeh C, Vallabhaneni S, Chandy S, Heylen E, Ekstrand M, Manasa J, McGrath N, Lessells R, Skingsley A, Newell M, de Oliveira T, Rawizza H, Chaplin B, Meloni S, Okonkwo P, Kanki P, Team T, Gale H, Gitterman S, Gordin F, Benator D, Kan V, Meya D, Rajasingham R, Rolfes M, Birkenkamp K, Boulware D, Bulterys P, Le T, Quang V, Nelson K, Lloyd‐Smith J, Luetkemeyer A, Rosenkranz S, Lu D, Lizak P, Ive P, Swindells S, Benson C, Grinsztejn B, Sanne I, Havlir D, Aweeka F, A5221 A, Sterling T, Benson C, Shang N, Miro J, Grinsztejn B, Chaisson R, Lucchetti A, Sanchez J, Scott N, Villarino E, Group T, McIlleron H, Martinson N, Denti P, Mashabela F, Hunt J, Shembe S, Hull J, Haas D, Msandiwa R, Cohn S, Chaisson R, Dooley K, Team T, Everitt D, Winter H, Egizi E, Everitt D, Murray S, Diacon A, Dawson R, Hutchings J, Van Niekerk C, Egizi E, Becker P, Hafkin J, Modongo C, Newcomb C, Lowenthal E, MacGregor R, Steenhoff A, Friedman H, Bisson G, Fitzgerald D, Jansen P, Chipungu C, Dindi V, Fielder J, Pfaff C, Bygrave H, Simons S, Munyaradzi D, Nyagadza B, Metcalf C, Ncube K, Van Den Broucke S, Mupfumi L, Mason P, Zinyowera S, Mutetwa R, Wallis R, Diacon A, Dawson R, Venter A, Friedrich S, Paige D, Zhu T, Silvia A, Gobey J, Ellery C, Zhang Y, Kadyszewski E, Brust J, Shah N, van der Merwe T, Bamber S, Mngadi A, Ning Y, Heo M, Moll A, Loveday M, Lalloo U, Friedland G, Gandhi N, Hawkins C, Christian B, Ye J, Nagu T, Aris E, Chalamilla G, Spiegelman D, Mugusi F, Mehta S, Fawzi W, Re V, Tate J, Kallan M, Lim J, Goetz M, Klein M, Rimland D, Rodriguez‐Barradas M, Butt A, Gibert C, Brown S, Kostman J, Strom B, Reddy R, Justice A, Localio R, Amorosa V, Umbleja T, Johnson V, Kang M, Luetkemeyer A, Bardin M, Haas D, Chung R, Yesmin S, Coughlin K, Martinez A, Adams M, Alston‐Smith B, Tebas P, Peters M, Kahn J, Xu J, Kapogiannis B, Rudy B, Liu N, Gonin R, Wilson C, Worrell C, Squires K, Kojic E, Cespedes M, Umbleja T, Kang M, Aberg J, Allen R, Grinsztein B, Firnhaber C, Webster‐Cyriaque J, Palefsky J, Godfrey C, Saah A, Cu‐Uvin S, Rangaka M, Boulle A, Wilkinson R, van Cutsem G, Goemaere E, Goliath R, Titus R, Mathee S, Maartens G, Shet A, Holla S, Raman V, Dinakar C, Ashok M, Dufouil C, Richert L, Bruyand M, Amieva H, Dauchy F, Dartigues J, Neau D, Dabis F, Morlat P, Bonnet F, Chene G, Group A, Nigo M, Walker A, Lucido D, Shah A, Skliut M, Mildvan D, Sahasrabuddhe V, Castle P, Follansbee S, Borgonovo S, LaMere B, Tokugawa D, Darragh T, Boyle S, Sadorra M, Tang S, Wentzensen N, Mills A, Mildvan D, Podzamczer D, Fätkenheuer G, Leal M, Than S, Valluri S, Craig C, Vourvahis M, Heera J, Valdez H, Brown T, Rinehart A, Portsmouth S, Gallant J, Koenig E, Andrade‐Villanueva J, Chetchotisakd P, Dejesus E, Antunes F, Arastéh K, Moyle G, Rizzardini G, Fehr J, Liu Y, Zhong L, Callebaut C, Ramanathan S, Szwarcberg J, Rhee M, Cheng A, Palella F, Tebas P, Gazzard B, Ruane P, Shamblaw D, Flamm J, Fisher M, van Lunzen J, Ebrahimi R, White K, Guyer B, Graham H, Fralich T, Elion R, Molina J, Arribas‐Lopez J, Cooper D, Maggiolo F, Wilkins E, Conway B, Liu Y, Zhong L, Margot N, Szwarcberg J, Rhee M, Cheng A, Raffi F, Rachlis A, Stellbrink H, Hardy W, Torti C, Orkin C, Bloch M, Podzamczer D, Pokrovsky V, Almond S, Margolis D, Min S, Team T, Karasi J, Musonera F, Iranyumviye K, Servais J, Devaux C, Binagwaho A, Arendt V, Shafer R, Zolopa A, Schmit J, Rimsky L, Van Eygen V, Vingerhoets J, Thys K, Aerssens J, Stevens M, Picchio G, van Zyl G, Claassen M, Engelbrecht S, de Oliveira T, Preiser W, Wood N, Travers S, Shafer R, Charpentier C, Landman R, Laouénan C, Joly V, Hamet G, Damond F, Brun‐Vézinet F, Mentré F, Descamps D, Yeni P, Grinsztejn B, De Castro N, Arnold V, Veloso V, Morgado M, Pilotto J, Brites C, Madruga J, Barcellos N, Santos B, Vorsatz C, Grondin C, Santini‐Oliveira M, Patey O, Delaugerre C, Chêne G, Molina J, group A, Venuto C, Mollan K, Ma Q, Daar E, Sax P, Fischl M, Collier A, Smith K, Lu D, Tierney C, Morse G, Team A, Haas D, Acosta E, Vardhanabhuti S, Ribaudo H, Severe P, Lalloo U, Kumarasamy N, Taulo F, Kabanda J, Oneko O, Ive P, Sambarey P, Chan E, Hitti J, McMahon D, Group F, Gandhi M, Greenblatt R, Bacchetti P, Jin C, Cohen M, Dehovitz J, Anastos K, Gange S, Liu C, Hanson S, Aouizerat B, Study W, Gervasoni C, Baldelli S, Cerea M, Meraviglia P, Landonio S, Simioni M, Gazzaniga A, Galli M, Rizzardini G, Clementi E, Cattaneo D, Grinsztejn B, Hosseinipour M, Swindells S, Ribaudo H, Eron J, Chen Y, Wang L, Ou S, Anderson M, McCauley M, Gamble T, Kumarasamy N, Hakim J, Kumwenda J, Pilotto J, Godbole S, Chariyalertsak S, Santos B, Mayer K, Eshleman S, Piwowar‐Manning E, Cottle L, Makhema J, Mills L, Panchia R, Sanne I, Elharrar V, Havlir D, Cohen M, Team F, Kanki P, Chang C, Meloni S, Rawizza H, Jolayemi T, Banigbe‐Aluko B, Okonkwo P, team H, Rewari B, Shaukat M, Kabra S, Srikantiah P, Lundgren J, Europe C, Colombero C, Rocco C, Mecikovsky D, Bologna R, Aulicino P, Sen L, Mangano A, Nielsen‐Saines K, Mirochnick M, Kumwenda N, Joao E, Kreitchmann R, Pinto J, Santos B, Parsons T, Richardson P, Taha T, Mofenson L, Sato P, Kearney B, Fowler M, Hazra R, Viani R, Acosta E, Zheng N, Alvero C, O'Gara E, Petzold E, Heckman B, Steimers D, Song I, Piscitelli S, Wiznia A, Team P, Cotton M, Cassim H, Pavía‐Ruz N, Ross L, Ford S, Givens N, Cheng K, Sievers J, Tudor‐Williams G, Cahn P, Chokephaibulkit K, Fourie J, Karatzios C, Dincq S, Kakuda T, Nijs S, Tambuyzer L, Tomaka F, Nachman S, Acosta E, Zheng N, Teppler H, Homony B, Xu X, Alvero C, Handelsman E, Worrell C, Graham B, Toye M, Petzold E, Wiznia A, Group A, Miruka A, Achieng R, Aoko A, Tarus J, Sigei C, Yegon P, Maswai J, Sawe F, Shaffer D, Crawford K, Kanjanavanit S, Puthanakit T, Kosalaraksa P, Hansudewechakul R, Ngampiyaskul C, Pinyakorn S, Luesomboon W, Vonthanak S, Ananworanich J, Ruxrungtham K, group P, Miller T, Wang J, Jacobson D, Takemoto J, Sharma T, Geffner M, Libutti D, Siminski S, Dooley L, Somarriba G, Graham P, Gerschenson M, van Ramshorst M, Struthers H, McIntyre J, Peters R, Himes S, Scheidweiler K, Tassiopoulos K, Kacanek D, Hazra R, Rich K, Huestis M, Study F, O'Brien M, Nardi M, Montenont E, Valdes V, Hu L, Merolla M, Gettenberg G, Aberg J, Bhardwaj N, Berger J, Kelesidis T, Kendall M, Yang O, Currier J, McComsey G, Kitch D, Sax P, Tierney C, Jahed N, Melbourne K, Ha B, Brown T, Bloom A, Fedarko N, Daar E, A5224s A, Schouten J, Wit F, Stolte I, van der Valk M, Geerlings S, de Wolf F, Prins M, Reiss P, Sax P, Sypek A, Morris B, Losina E, Paltiel A, Seage G, Walensky R, Weinstein M, Eron J, Freedberg K. Track B Clinical Science. Journal Of The International AIDS Society 2012, 15: 18439-01. PMCID: PMC3499900, DOI: 10.7448/ias.15.5.18439.Peer-Reviewed Original ResearchSecond-line antiretroviral therapyFirst-line antiretroviral therapyPlasma HIV-1 RNANNRTI resistance-associated mutationsHIV-1-infected adultsIsoniazid preventive therapyRitonavir-boosted protease inhibitorAcute HIV infectionCardiovascular risk factorsCD4 cell countCombination antiretroviral therapyHIV-1-infected patientsSerious adverse eventsATV/rCells/mm3Genotypic resistance testingGeometric mean titersLow-level viremiaTDF/FTCCommon adverse eventsCAP/CTMBody mass indexHIV-1 RNAAZT/3TC/nevirapineAZT/3TC/NVP
2011
Rationale, study design and sample characteristics of a randomized controlled trial of directly administered antiretroviral therapy for HIV-infected prisoners transitioning to the community — A potential conduit to improved HIV treatment outcomes
Saber-Tehrani AS, Springer SA, Qiu J, Herme M, Wickersham J, Altice FL. Rationale, study design and sample characteristics of a randomized controlled trial of directly administered antiretroviral therapy for HIV-infected prisoners transitioning to the community — A potential conduit to improved HIV treatment outcomes. Contemporary Clinical Trials 2011, 33: 436-444. PMID: 22101218, PMCID: PMC3268833, DOI: 10.1016/j.cct.2011.11.002.Peer-Reviewed Original ResearchConceptsHIV treatment outcomesSelf-administered therapyAntiretroviral therapyTreatment outcomesViral loadEvidence-based adherence interventionsPoor HIV treatment outcomesGenotypic resistance testingMedication-Assisted TreatmentDSM-IV criteriaAlcohol use disorderCase management servicesViral suppressionPrimary outcomeOpioid dependenceAdherence interventionsCD4 testingIntervention periodStudy groupEligibility criteriaUse disordersIntervention monthDrug usersAdverse HIVHIV
2007
Directly Administered Antiretroviral Therapy for HIV-Infected Drug Users Does Not Have an Impact on Antiretroviral Resistance
Maru DS, Kozal MJ, Bruce RD, Springer SA, Altice FL. Directly Administered Antiretroviral Therapy for HIV-Infected Drug Users Does Not Have an Impact on Antiretroviral Resistance. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2007, 46: 555-563. PMID: 18193497, PMCID: PMC2684061, DOI: 10.1097/qai.0b013e318158c0bd.Peer-Reviewed Original ResearchConceptsDrug resistance mutationsNew drug resistance mutationsSelf-administered therapyDrug usersAntiretroviral therapyHIV genotypic resistance testingFuture drug optionsAntiretroviral drug resistanceGenotypic resistance testingGenotypic sensitivity scoreMain outcome measuresMedication resistanceModified intentionVirologic benefitAntiretroviral resistanceTreat analysisClinical outcomesDrug mutationsDrug optionsOutcome measuresAdjusted probabilityDrug resistanceResistance mutationsHIVEffective interventions
2006
Treatment Benefit on Cerebrospinal Fluid HIV‐1 Levels in the Setting of Systemic Virological Suppression and Failure
Spudich S, Lollo N, Liegler T, Deeks SG, Price RW. Treatment Benefit on Cerebrospinal Fluid HIV‐1 Levels in the Setting of Systemic Virological Suppression and Failure. The Journal Of Infectious Diseases 2006, 194: 1686-1696. PMID: 17109340, DOI: 10.1086/508750.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsCSF HIV-1 RNA levelsPlasma HIV-1 RNA levelsRNA levelsAntiretroviral therapyCSF inflammationCopies/Successful therapyPlasma HIV-1 RNA assaysHIV-1 RNA assaysHIV-1-infected subjectsSuppressive combination antiretroviral therapyDrug resistanceHIV-1 levelsCombination antiretroviral therapyHIV-negative subjectsGenotypic resistance testingFailure of therapyHuman immunodeficiency virusCopies/mLSubset of subjectsActive neurological diseaseCross-sectional analysisVirological suppressionImmunodeficiency virus
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