2017
Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches
Schaefer SM, Rodriguez A, Louis ED. Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches. Expert Review Of Neurotherapeutics 2017, 18: 101-110. PMID: 29206482, DOI: 10.1080/14737175.2018.1413353.Peer-Reviewed Original ResearchConceptsEssential tremorGABA systemReceptor subtypesΓ-aminobutyric acid (GABA) neurotransmissionT-type calcium channelsHuman data pointUnderlying biochemical dysfunctionGABA-ergic neuronsRole of GABAInferior olivary nucleusPurkinje cell outputCertain GABANumerous medicationsClinical guidelinesPharmacotherapeutic approachesOlivary nucleusGABA receptorsPubMed searchCalcium channelsBiochemical dysfunctionNeurochemical systemsBrain circuitsMedicationsDegeneration modelGABA
2009
GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation
Dave KA, Bordey A. GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation. IUBMB Life 2009, 61: 496-503. PMID: 19391160, PMCID: PMC2675662, DOI: 10.1002/iub.185.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidRole of GABAVertebrate central nervous systemComplement of receptorsCerebellar granule cell precursorsCell precursorsGranule cell precursorsDevelopmental processesMetabotropic glutamate receptorsCentral nervous systemCell proliferationAdult mammalsNovel targetAmino acid glutamatePharmacological regulationCurrent knowledgeGlutamate receptorsNeural cancersNervous systemCerebellar tumorsCalcium increaseReceptorsProliferationMammalsNovel data
2005
GABA and glutamate systems as therapeutic targets in depression and mood disorders
Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opinion On Therapeutic Targets 2005, 9: 153-168. PMID: 15757488, DOI: 10.1517/14728222.9.1.153.Peer-Reviewed Original Research
1999
GABA Changes with Vigabatrin in the Developing Human Brain
Novotny E, Hyder F, Shevell M, Rothman D. GABA Changes with Vigabatrin in the Developing Human Brain. Epilepsia 1999, 40: 462-466. PMID: 10219272, DOI: 10.1111/j.1528-1157.1999.tb00741.x.Peer-Reviewed Original ResearchConceptsBrain GABA levelsGABA levelsBrain GABAVGB treatmentRole of GABASeizure controlGABA changesSeizure susceptibilityPediatric epilepsyEpileptic focusOccipital lobeNervous systemEpileptic regionsVigabatrinEpilepsyGABAGABA metabolismTreatmentAge 1Noninvasive measurementHuman brainSubjectsDrugsFivefold increaseChildren
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