Immunohistochemical expression of folate receptor α in colorectal carcinoma: patterns and biological significance
Shia J, Klimstra D, Nitzkorski J, Low P, Gonen M, Landmann R, Weiser M, Franklin W, Prendergast F, Murphy L, Tang L, Temple L, Guillem J, Wong W, Paty P. Immunohistochemical expression of folate receptor α in colorectal carcinoma: patterns and biological significance. Human Pathology 2008, 39: 498-505. PMID: 18342661, DOI: 10.1016/j.humpath.2007.09.013.Peer-Reviewed Original ResearchConceptsFRalpha expressionColorectal carcinomaPrimary carcinomaMicrosatellite instability statusPositive stainingPresence of distant metastasesColorectal tissuesMetastatic colorectal carcinomaDisease-specific survivalInstability statusFolate receptor alphaTherapy of colorectal tumoursFeasibility of immunohistochemistryReverse transcriptase polymerase chain reactionTranscriptase polymerase chain reactionParaffin-embedded tissuesColorectal mucosa samplesDistant metastasisPrognostic significanceCancer therapy targetPrognostic valueImmunohistochemical expressionTissue microarrayReceptor ANormal mucosa
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