2024
Dynamin-1 is a potential mediator in cancer-related cognitive impairment
Ng D, Hudson C, Nguyen T, Gupta S, Koh Y, Acharya M, Chan A. Dynamin-1 is a potential mediator in cancer-related cognitive impairment. Neurotherapeutics 2024, 22: e00480. PMID: 39516074, PMCID: PMC11742811, DOI: 10.1016/j.neurot.2024.e00480.Peer-Reviewed Original ResearchConceptsCancer-related cognitive impairmentFemale mouse modelNon-cancer controlsSpatial recognition memoryConsequences of cancer treatmentYoung adult cancerCytotoxic treatmentControl miceHippocampal CA1Cancer patientsMouse modelSynaptic activityAdult cancersCA3 subregionNeurological consequencesAnimal modelsCognitive impairmentAnimal studiesHuman studiesCancer treatmentNon-cancer participantsTherapeutic targetCancerExposure to cancerChemotherapy
2023
Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons
Dorskind J, Sudarsanam S, Hand R, Ziak J, Amoah-Dankwah M, Guzman-Clavel L, Soto-Vargas J, Kolodkin A. Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons. Journal Of Neuroscience 2023, 43: 7745-7765. PMID: 37798130, PMCID: PMC10648559, DOI: 10.1523/jneurosci.0553-23.2023.Peer-Reviewed Original ResearchConceptsLoss-of-functionCollateral axonal branchingMolecular mechanismsF-actin bundlesStructure-function analysisCircuit formationAxon collateral branchesCortical circuit formationAxonal branchesPyramidal excitatory neuronsLoss-of-function experimentsFemale mouse modelProtein domainsF-actinCortical neuronal morphologyLaminar-specific mannerBranch initiationGene expressionSynaptic partnersSingle-cell labelingAxonal protrusionsDrebrinExcitatory neuronsSomatosensory neuronsDBN1
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