Single-Cell Multi-Omics Reveals Type-2 Functionality in Maintaining CAR T Cell Longevity Associated with 8-Year Leukemia Remission
Bai Z, Feng B, Mcclory S, Diorio C, Zhao Z, Tang L, Melenhorst J, June C, Grupp S, Fan R. Single-Cell Multi-Omics Reveals Type-2 Functionality in Maintaining CAR T Cell Longevity Associated with 8-Year Leukemia Remission. Blood 2023, 142: 352. DOI: 10.1182/blood-2023-179480.Peer-Reviewed Original ResearchChimeric antigen receptor T cellsCAR-T cellsChimeric antigen receptorType 2 cytokinesB-cell aplasiaT cellsAcute lymphocytic leukemiaCAR-T persistenceIL-4CAR-TType 1Validation cohortCAR T infusionSurvival of tumor-bearing miceDiscovery cohortPersistent CAR T cellsDose of tumor cellsLevels of type 2 cytokinesType 2 cytokine levelsNSG mouse modelPediatric ALL patientsLong-term remissionReduced tumor burdenT cell longevityType 1 cytokinesLow Dose Total Body Irradiation Improves CD19 CAR-T Expansion, Persistence, and Trafficking, Leading to Enhanced Efficacy in Large B-Cell Lymphoma
Alhomoud M, Foley M, Sugita M, Yamazaki T, Martinez L, Yamshon S, Gomez-Arteaga A, Pagnini P, Shore T, Boyer O, Brentjens R, Van Besien K, Galluzzi L, Formenti S, Martinet J, Guzman M. Low Dose Total Body Irradiation Improves CD19 CAR-T Expansion, Persistence, and Trafficking, Leading to Enhanced Efficacy in Large B-Cell Lymphoma. Blood 2023, 142: 1016. DOI: 10.1182/blood-2023-185216.Peer-Reviewed Original ResearchLow-dose total body irradiationLarge B-cell lymphomaDose total body irradiationTotal body irradiationSyngeneic mouse modelB-cell lymphomaComplete remissionDays post treatmentExpression of FasBody irradiationSecond dosePeripheral bloodGy radiationMouse modelAnti-CD19 Chimeric Antigen Receptor T CellsA20 cellsChimeric antigen receptor T cellsAntigen receptor T cellsBALB/c miceB-cell recoveryAdditional survival benefitB-cell aplasiaReceptor T cellsImmunosuppressive tumor microenvironmentBone marrow aspirate
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