Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure
Løkhammer S, Tesfaye M, Cabrera-Mendoza B, Sandås K, Pathak G, Friligkou E, Le Hellard S, Polimanti R. Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure. Biological Psychiatry Global Open Science 2025, 5: 100482. PMID: 40270839, PMCID: PMC12013147, DOI: 10.1016/j.bpsgos.2025.100482.Peer-Reviewed Original ResearchPosttraumatic stress disorderLocal genetic correlationImaging-derived phenotypesBrain imaging-derived phenotypesStress disorderAssociated with posttraumatic stress disorderDevelopment of posttraumatic stress disorderExposure to severe traumatic eventsGenetic correlationsGenome-wide dataSevere traumatic eventsBrain frontal cortexBrain imaging markersFrontal cortexLeft pallidumMap genesGenetic regionsGlycoprotein acetylsTraumatic eventsMetabolic biomarkersGenetic relationshipsTranscriptome regulationGenetic overlapStress responseMetabolic processes
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