2010
Cholangiocyte Biology as Relevant to Cystic Liver Diseases
Lecchi S, Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Cholangiocyte Biology as Relevant to Cystic Liver Diseases. Clinical Gastroenterology 2010, 23-43. DOI: 10.1007/978-1-60327-524-8_2.ChaptersLiver cystsLiver diseaseSevere life-threatening complicationsIntrahepatic bile duct epitheliumComplex intercellular signalingCystic liver diseaseProgressive cyst growthLife-threatening complicationsEpithelial cellsBile duct epitheliumIntrahepatic biliary treePolycystic liver diseaseExcessive fluid secretionRenal tubule epitheliumRecessive formExtracellular matrix remodelingBiliary treeBiliary epitheliumCystic diseaseDuct epitheliumCyst expansionCyst growthAutocrine mechanismTubule epitheliumHereditary disorder
1992
cGMP-dependent protein kinase regulation of a chloride channel in T84 cells
Lin M, Nairn A, Guggino S. cGMP-dependent protein kinase regulation of a chloride channel in T84 cells. American Journal Of Physiology 1992, 262: c1304-c1312. PMID: 1317106, DOI: 10.1152/ajpcell.1992.262.5.c1304.Peer-Reviewed Original ResearchConceptsProtein kinaseChloride channelsIntestinal epithelial cellsCGMP-dependent protein kinaseProtein kinase regulationApical membraneDependent protein kinaseT84 cellsEpithelial cellsInhibitor of PKGKinase regulationCatalytic subunitCombination of ATPNonhydrolyzable formExcessive fluid secretionIntracellular faceEscherichia coliElevated guanosineSingle-channel recordingsATPKinasePKGLinear current-voltage relationshipCellsChloride secretion
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