2023
The Administration of Tranexamic Acid For Complex Spine Surgery.
Jockel K, Lee A, Cosgrove M, Reilly D, Wijesekera S. The Administration of Tranexamic Acid For Complex Spine Surgery. AANA Journal 2023, 91: 63-70. PMID: 36722785.Peer-Reviewed Educational MaterialsConceptsComplex spine surgeryPerioperative blood lossBlood lossTranexamic acidSpine surgeryExtensive vascular networkHigh-dose tranexamic acidLow-dose tranexamic acidUse of TXASubstantial intraoperative blood lossMultilevel spine surgeryBlood product utilizationIntraoperative blood lossMajor blood lossExcessive blood lossInstrumented spinal surgeryAntifibrinolytic medicationsTransfusion requirementsHospital lengthPerioperative morbidityPostoperative morbidityPerioperative periodBlood transfusionSpinal surgeryTopical administration
2022
LC–MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first‐in‐human pharmacokinetic study
Wu J, Zheng L, Zhang Q, Zhang Q, Qin H, Zhou R, Chu Z, He G, Wang L, Hu W. LC–MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first‐in‐human pharmacokinetic study. Biomedical Chromatography 2022, 37: e5542. PMID: 36330676, DOI: 10.1002/bmc.5542.Peer-Reviewed Original ResearchConceptsAtopic dermatitisClinical developmentActive metabolitePhosphodiesterase 4 inhibitorNovel phosphodiesterase 4 inhibitorClinical trialsSimple liquid-liquid extraction methodTopical administrationHealthy humansSensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodHuman pharmacokinetic studiesPg/Liquid chromatography-tandem mass spectrometry methodChromatography-tandem mass spectrometry methodPositive ion modeLiquid chromatographic separationPharmacokinetic studyPlasma samplesMultiple reaction monitoringLiquid-liquid extraction methodMass spectrometry methodLC-MS/MS determinationDermatitisMS/MS quantificationIon mode
2020
The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model
Vageli DP, Kasle D, Doukas SG, Doukas PG, Sasaki CT. The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model. Oncotarget 2020, 11: 3303-3314. PMID: 32934775, PMCID: PMC7476734, DOI: 10.18632/oncotarget.27706.Peer-Reviewed Original ResearchNF-κB inhibitorBAY 11NF-κB-related pathwaysPharmacological NF-κB inhibitorSquamous cell cancerPro-inflammatory effectsNF-κB inhibitionNF-κB activationOncogenic mRNAsAcidic bileTopical preBile refluxHypopharyngeal cancerCell cancerPreclinical modelsTopical administrationHypopharyngeal mucosaBile exposureVivo preventionTranslational explorationMiR-155MiR-21Oncogenic eventsMiRNA phenotypesPrevents overexpression
2015
Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression
Yabumoto C, Akazawa H, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I. Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression. Scientific Reports 2015, 5: 14453. PMID: 26571361, PMCID: PMC4585890, DOI: 10.1038/srep14453.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAgingAngiotensin II Type 1 Receptor BlockersAnimalsAxin ProteinBiphenyl CompoundsCell LineComplement C1qDown-RegulationImmunohistochemistryIrbesartanMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalPAX7 Transcription FactorReceptor, Angiotensin, Type 1RegenerationTetrazolesWnt Signaling PathwayConceptsC1q expressionReceptor blockadeAge-related declineAngiotensin II receptor blockadeAT1 receptor blocker irbesartanAngiotensin II type 1 receptorII type 1 receptorAT1 receptor blockadeFunctional muscle recoveryII receptor blockadeSkeletal muscleReceptor blocker irbesartanType 1 receptorWnt/β-catenin pathwaySkeletal muscle functionWnt/β-catenin signalingMuscle regenerationΒ-catenin pathwayCultured macrophage cellsΒ-catenin signalingAT1 receptorMuscle recoveryM2 polarizationMuscle functionTopical administration
2013
Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye
Nabili M, Patel H, Mahesh SP, Liu J, Geist C, Zderic V. Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye. Ultrasound In Medicine & Biology 2013, 39: 638-646. PMID: 23415283, PMCID: PMC3770302, DOI: 10.1016/j.ultrasmedbio.2012.11.010.Peer-Reviewed Original ResearchConceptsOphthalmic drugsLong-term survival studiesSodium fluoresceinAnti-inflammatory drugsTreatment parameter combinationUltrasound-enhanced deliveryTopical administrationHistologic analysisSurvival studiesCorneaCorneal permeabilityDexamethasoneEpithelial layerTherapeutic drugsRabbit corneaStatistical significanceDrug dexamethasoneDrugsTobramycinUltrasoundEyesDeliveryFuture investigationsAdministrationDrug delivery
2007
Cutaneous two-stage chemical carcinogenesis.
Filler RB, Roberts SJ, Girardi M. Cutaneous two-stage chemical carcinogenesis. Cold Spring Harbor Protocols 2007, 2007: pdb.prot4837. PMID: 21357170, DOI: 10.1101/pdb.prot4837.Peer-Reviewed Original ResearchTwo-stage chemical carcinogenesisChemical carcinogenesisCutaneous malignanciesCutaneous tumorsCutaneous carcinogenesisBenign papillomasImmunological pathwaysPrecursor lesionsTopical administrationPro-inflammatory phorbol estersCancer developmentMouse skinTumor susceptibilityCarcinogenesisTumorsProgressionPhorbol esterLate eventSkinInductionMalignancyPapillomasLesionsMiceAdministration
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