2018
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis
Chen Y, Han M, Matsumoto A, Wang Y, Thompson DC, Vasiliou V. Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis. Advances In Experimental Medicine And Biology 2018, 1032: 37-53. PMID: 30362089, PMCID: PMC6743726, DOI: 10.1007/978-3-319-98788-0_3.ChaptersConceptsGSH biosynthesisAbundant non-protein thiolEpigenetic gene regulationNon-protein thiolsGlutathione S-transferase (GST) familyGene regulationPeroxidase familyExogenous electrophilesCellular methylationReactive oxygen speciesGSH functionsCellular concentrationRelated enzymesTranssulfuration pathwayCancer developmentOxygen speciesBiosynthesisExogenous chemicalsEnzymeTransmethylation pathwayEnhanced susceptibilityPathological conditionsIntimate involvementMillimolar rangePathway
2016
Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo
Chuang YM, Dutta NK, Hung CF, Wu TC, Rubin H, Karakousis PC. Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo. Antimicrobial Agents And Chemotherapy 2016, 60: 6460-6470. PMID: 27527086, PMCID: PMC5075050, DOI: 10.1128/aac.01139-16.Peer-Reviewed Original ResearchMeSH KeywordsAcid Anhydride HydrolasesAnimalsAntitubercular AgentsBiofilmsCitric Acid CycleClofazimineDisease Models, AnimalDrug Resistance, BacterialGene ExpressionGlycerophosphatesIsoenzymesIsoniazidMeropenemMiceMycobacterium tuberculosisNaphthoquinonesPhosphotransferases (Phosphate Group Acceptor)PolyphosphatesThienamycinsTuberculosis VaccinesTuberculosis, Multidrug-ResistantVaccines, DNAXyloseConceptsM. tuberculosisVaccine-induced immunityGlobal health threatActivity of isoniazidMedical nonadherenceChronic tuberculosisProlonged therapyDNA vaccineAntibiotic treatmentMycobacterium tuberculosis metabolismReal-time PCRMurine modelM. tuberculosis metabolismAntibiotic toleranceLow intracellular levelsProtective activityAntibiotic sensitivityDrug resistanceTuberculosisLiquid chromatography-tandem mass spectrometryMycobacterium tuberculosisHealth threatKey regulatory moleculesChromatography-tandem mass spectrometryEnhanced susceptibility
2012
Retinoic Acid–related Orphan Receptor-α Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema
Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D. Retinoic Acid–related Orphan Receptor-α Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema. American Journal Of Respiratory And Critical Care Medicine 2012, 186: 412-419. PMID: 22744720, PMCID: PMC5450975, DOI: 10.1164/rccm.201111-2023oc.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCells, CulturedDisease Models, AnimalDNA DamageDNA RepairGene Expression ProfilingHumansLungMiceMice, Inbred C57BLMice, Neurologic MutantsNuclear Receptor Subfamily 1, Group F, Member 1Oligonucleotide Array Sequence AnalysisPulmonary Disease, Chronic ObstructivePulmonary EmphysemaTobacco Smoke PollutionConceptsRetinoic acid-related orphan receptorAcid-related orphan receptorCigarette smoke extractLungs of patientsPathogenesis of emphysemaRORA expressionCigarette smokeAirspace enlargementSmoke extractCigarette smoke exposureSmoke-induced emphysemaOrphan receptorDNA damageActive smokingLung transplantationSmoke exposureLung cancerPulmonary emphysemaLung tissueEmphysemaPatientsGene expression profilingApoptotic cell deathMiceEnhanced susceptibility
2008
Balancing Immunity and Immunosuppression: Vaccinating Patients Receiving Treatment with Efalizumab
Marmon S, Strober B. Balancing Immunity and Immunosuppression: Vaccinating Patients Receiving Treatment with Efalizumab. Journal Of Investigative Dermatology 2008, 128: 2567-2569. PMID: 18927537, DOI: 10.1038/jid.2008.291.Peer-Reviewed Original Research
2001
ICOS co-stimulatory receptor is essential for T-cell activation and function
Dong C, Juedes A, Temann U, Shresta S, Allison J, Ruddle N, Flavell R. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001, 409: 97-101. PMID: 11343121, DOI: 10.1038/35051100.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody FormationAntigens, CDAntigens, Differentiation, T-LymphocyteCell DifferentiationCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalGene TargetingHemocyaninsInducible T-Cell Co-Stimulator ProteinInterleukin-13Interleukin-4Lymph NodesLymphocyte ActivationMiceMice, KnockoutMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinT-LymphocytesConceptsInducible co-stimulatory moleculeT cell activationCo-stimulatory moleculesT cellsICOS-/- miceICOS-deficient miceInflammatory autoimmune diseaseExperimental autoimmune encephalomyelitisInjection of lipopolysaccharideCo-stimulatory receptorsHumoral immune responseNon-immune tissuesT lymphocyte activationAutoimmune encephalomyelitisAutoimmune diseasesImmune responseInterleukin-4Immune functionCD28/CTLA4 familyB cellsProtective roleEnhanced susceptibilityActivationReceptorsHigh affinity
1990
Enhanced Susceptibility to Histamine-Induced Cardiac Arrhythmias in Spontaneously Hypertensive Rats
Cameron J, Swigart C, Shin G, Katz D, Bassett A. Enhanced Susceptibility to Histamine-Induced Cardiac Arrhythmias in Spontaneously Hypertensive Rats. Journal Of Cardiovascular Pharmacology 1990, 15: 626-632. PMID: 1691394, DOI: 10.1097/00005344-199004000-00016.Peer-Reviewed Original ResearchConceptsIncidence of arrhythmiasSpontaneous firing rateAction potential durationHypertensive ratsH2-receptor blocker cimetidineFiring rateElevated intracellular calcium levelsSpontaneously Hypertensive RatsBody weight ratioLevels of repolarizationCardiac rhythm disturbancesChannel antagonist verapamilAge-matched controlsIntracellular calcium levelsEnhanced susceptibilitySHR ventriclesWKY preparationsSHR heartsAntagonist verapamilArrhythmogenic influenceRhythm disturbancesHistamine releaseMyocardial hypertrophySHR myocardiumDrug levels
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