2021
HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation
Holzman MA, Ryckman A, Finkelstein TM, Landry-Truchon K, Schindler KA, Bergmann JM, Jeannotte L, Mansfield JH. HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation. Frontiers In Cell And Developmental Biology 2021, 9: 632303. PMID: 33732701, PMCID: PMC7959767, DOI: 10.3389/fcell.2021.632303.Peer-Reviewed Original ResearchSkeletal muscle fateNull mutant embryosBAT developmentBrown adipocyte differentiationEmbryonic day 12.5Muscle fateBrown adipose tissueSkeletal muscleMutant embryosHOXA5 proteinLipid droplet morphologyForelimb levelEmbryonic developmentMolecular roleMuscle developmentLineage tracingMuscle patterningCommon progenitorDependent regulationMuscle phenotypeAdipocyte differentiationMultiple tissuesConditional deletionDay 12.5Progenitors
2011
Cell organization, growth, and neural and cardiac development require αII-spectrin
Stankewich MC, Cianci CD, Stabach PR, Ji L, Nath A, Morrow JS. Cell organization, growth, and neural and cardiac development require αII-spectrin. Journal Of Cell Science 2011, 124: 3956-3966. PMID: 22159418, PMCID: PMC3244980, DOI: 10.1242/jcs.080374.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAnkyrinsAxonsBody PatterningCarrier ProteinsCell MembraneCell PolarityCell ProliferationCraniofacial AbnormalitiesEmbryo, MammalianEmbryonic DevelopmentFemaleFibroblastsGene DeletionHeart Defects, CongenitalMaleMiceMice, Inbred C57BLMicrofilament ProteinsNeural Tube DefectsNeuroepithelial CellsPhenotypeProtein StabilityPseudopodiaSpectrinConceptsΑII-spectrinSteady-state protein levelsΒIII spectrinEmbryonic day 12.5Tissue patterningRenal epithelial cellsEmbryonic lethalCortical actinOrgan developmentAnkyrin BExon trappingEmbryonic fibroblastsTranscriptional levelΒ-spectrinCardiac developmentCell organizationCell spreadingAxon formationNeural tubeHeterozygous animalsTargeted disruptionApical membraneNeuroepithelial cellsDay 12.5Cell morphologyFGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis
Rash BG, Lim HD, Breunig JJ, Vaccarino FM. FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis. Journal Of Neuroscience 2011, 31: 15604-15617. PMID: 22031906, PMCID: PMC3235689, DOI: 10.1523/jneurosci.4439-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsBrainBromodeoxyuridineCaspase 3Cell CountCell DifferentiationCells, CulturedCerebral CortexDNA-Binding ProteinsElectroporationEmbryo, MammalianEye ProteinsFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFibroblast Growth FactorsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHomeodomain ProteinsKi-67 AntigenMiceMice, TransgenicMutationNerve Tissue ProteinsNeurogenesisNeuronsPaired Box Transcription FactorsPAX6 Transcription FactorReceptors, Fibroblast Growth FactorReceptors, NotchRepressor ProteinsSignal TransductionStem CellsT-Box Domain ProteinsTranscription FactorsConceptsCortical neurogenesisCortical surface area expansionCortical surface expansionCortical surface areaGrowth factor receptorEmbryonic day 12.5Fibroblast growth factor receptorFGFR mutantsNormal miceCortical layer structureCortical developmentNeurogenic stagesDominant negative FGFRLoss of functionRadial progenitorsNeurogenesisNotch pathway genesSevere deficitsFactor receptorDay 12.5Notch pathwayMiceSimultaneous activationGreater proportionFGFR activity
2006
Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro
Chung S, Shin B, Hwang M, Lardaro T, Kang U, Isacson O, Kim K. Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro. Stem Cells 2006, 24: 1583-1593. PMID: 16543488, PMCID: PMC2613224, DOI: 10.1634/stemcells.2005-0558.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBrain Tissue TransplantationCell DifferentiationCells, CulturedCryopreservationDNA, ComplementaryDopa DecarboxylaseDopamineDopamine Plasma Membrane Transport ProteinsEmbryo, MammalianFibroblast Growth Factor 2In Vitro TechniquesMesencephalonMiceMultipotent Stem CellsNeuronsRNA, MessengerStem Cell TransplantationTyrosine 3-MonooxygenaseConceptsVentral mesencephalonDA markersExpansion in vitroIn vitro expansionNeural precursorsDA neuronsDevelopmental potentialMidbrain DA markersFetal ventral mesencephalonEmbryonic stemES cellsTyrosine hydroxylase-positiveNeurons in vivoEmbryonic day 12.5Low passage numberEmbryonic stem cellsDopamine transporterIn vivo characteristicsMouse striatumDay 12.5Dopaminergic neuronsTumor formationStem cellsCell sourceNeurons
2000
Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2α
Kramer P, Guerrero G, Krishnamurthy R, Mitchell P, Wray S. Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2α. Cells And Development 2000, 94: 79-94. PMID: 10842061, DOI: 10.1016/s0925-4773(00)00316-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationDNA-Binding ProteinsEmbryonic InductionEpithelial CellsFemaleGene Expression Regulation, DevelopmentalGonadotropin-Releasing HormoneIntermediate Filament ProteinsMaleMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Mutant StrainsNasal CavityNerve Tissue ProteinsNeural Cell Adhesion MoleculesNeuronsOlfactory MucosaOlfactory PathwaysPeripherinsTrans-ActivatorsTranscription Factor AP-2Transcription FactorsConceptsLHRH neuronsHormone-releasing hormoneRespiratory epitheliumNeural cell adhesion moleculeOlfactory epitheliumExpression of LHRHPeripherin-positive fibersNasal placodeIntermediate filament protein peripherinMain olfactory epitheliumTranscription factor APOlfactory epithelial structuresAP-2alphaOlf-1Embryonic day 12.5NCAM stainingCell adhesion moleculeEpithelial areaAP-2alpha expressionMutant miceCell groupsProtein peripherinAdhesion moleculesNeuronsEpithelium
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