2020
Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism
Blackburn JK, Curry DW, Thomsen AN, Roth RH, Elsworth JD. Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism. Experimental Neurology 2020, 327: 113234. PMID: 32044330, PMCID: PMC7089823, DOI: 10.1016/j.expneurol.2020.113234.Peer-Reviewed Original ResearchConceptsParaoxonase 2Novel neuroprotective mechanismParaoxonase-2 expressionAnti-diabetic drug pioglitazoneReactive oxygen species productionNeuroprotective strategiesNeuroprotective mechanismsBrain traumaMouse striatumOxygen species productionParkinson's diseaseAlzheimer's diseaseTherapeutic potentialPioglitazoneDiseaseOxidative stressDrug pioglitazoneSpecies productionBrainNeuroprotectionIschemiaStriatumExpressionPathologyTrauma
2011
Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity
Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E. Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity. Journal Of Neuroscience 2011, 31: 8150-8162. PMID: 21632937, PMCID: PMC3472648, DOI: 10.1523/jneurosci.3446-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCalcineurinCell DeathDisease Models, AnimalGene Expression RegulationGene Products, tatHuntingtin ProteinHuntington DiseaseMiceMice, Neurologic MutantsMice, TransgenicMicroinjectionsNerve Tissue ProteinsNuclear ProteinsPhosphorylationProtein Tyrosine Phosphatases, Non-ReceptorQuinolinic AcidSignal TransductionConceptsStriatal-enriched protein tyrosine phosphataseCell deathSTEP expressionPhosphorylation levelsProtein Tyrosine Phosphatase ExpressionProtein tyrosine phosphataseSTEP phosphorylationTyrosine phosphataseProtein kinasePhosphorylated ERK2Phosphatase expressionHuntington's diseaseSTEP proteinMutant huntingtinCalcineurin activityPhosphorylationExon 1STEP protein levelsDisease mouse modelProtein levelsMouse modelMouse striatumTAT-STEPHuntington's disease mouse modelExpressionHigh levels of histidine decarboxylase in the striatum of mice and rats
Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C. High levels of histidine decarboxylase in the striatum of mice and rats. Neuroscience Letters 2011, 495: 110-114. PMID: 21440039, PMCID: PMC3081964, DOI: 10.1016/j.neulet.2011.03.050.Peer-Reviewed Original ResearchConceptsPosterior hypothalamusBasal gangliaHistamine receptorsHistidine decarboxylaseHDC knockout miceStriatum of miceCentral nervous systemHDC proteinTuberomamillary nucleusFunctional innervationHistamine metabolismAxonal projectionsMouse striatumHigh levelsKnockout miceForebrain structuresHistamine levelsNervous systemStriatumNeurotransmitter histamineWestern blotHypothalamusRatsMiceSimilar high levels
2006
Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro
Chung S, Shin B, Hwang M, Lardaro T, Kang U, Isacson O, Kim K. Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro. Stem Cells 2006, 24: 1583-1593. PMID: 16543488, PMCID: PMC2613224, DOI: 10.1634/stemcells.2005-0558.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBrain Tissue TransplantationCell DifferentiationCells, CulturedCryopreservationDNA, ComplementaryDopa DecarboxylaseDopamineDopamine Plasma Membrane Transport ProteinsEmbryo, MammalianFibroblast Growth Factor 2In Vitro TechniquesMesencephalonMiceMultipotent Stem CellsNeuronsRNA, MessengerStem Cell TransplantationTyrosine 3-MonooxygenaseConceptsVentral mesencephalonDA markersExpansion in vitroIn vitro expansionNeural precursorsDA neuronsDevelopmental potentialMidbrain DA markersFetal ventral mesencephalonEmbryonic stemES cellsTyrosine hydroxylase-positiveNeurons in vivoEmbryonic day 12.5Low passage numberEmbryonic stem cellsDopamine transporterIn vivo characteristicsMouse striatumDay 12.5Dopaminergic neuronsTumor formationStem cellsCell sourceNeurons
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply