Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro
Chung S, Shin B, Hwang M, Lardaro T, Kang U, Isacson O, Kim K. Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro. Stem Cells 2006, 24: 1583-1593. PMID: 16543488, PMCID: PMC2613224, DOI: 10.1634/stemcells.2005-0558.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBrain Tissue TransplantationCell DifferentiationCells, CulturedCryopreservationDNA, ComplementaryDopa DecarboxylaseDopamineDopamine Plasma Membrane Transport ProteinsEmbryo, MammalianFibroblast Growth Factor 2In Vitro TechniquesMesencephalonMiceMultipotent Stem CellsNeuronsRNA, MessengerStem Cell TransplantationTyrosine 3-MonooxygenaseConceptsVentral mesencephalonDA markersExpansion in vitroIn vitro expansionNeural precursorsDA neuronsDevelopmental potentialMidbrain DA markersFetal ventral mesencephalonEmbryonic stemES cellsTyrosine hydroxylase-positiveNeurons in vivoEmbryonic day 12.5Low passage numberEmbryonic stem cellsDopamine transporterIn vivo characteristicsMouse striatumDay 12.5Dopaminergic neuronsTumor formationStem cellsCell sourceNeurons
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