2024
Abstract 1147: Crosstalk Between Alk5 And Mtorc1 Signaling Promotes VSMC Differentiation And The Therapeutic Effect Of Rapamycin
Chakraborty R, Chatterjee P, Dave J, Obrien B, Joshi D, Schulz V, Greif D, Hwa J, Gallagher P, Martin K. Abstract 1147: Crosstalk Between Alk5 And Mtorc1 Signaling Promotes VSMC Differentiation And The Therapeutic Effect Of Rapamycin. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a1147-a1147. DOI: 10.1161/atvb.44.suppl_1.1147.Peer-Reviewed Original ResearchVascular smooth muscle cellsTherapeutic effect of rapamycinEffects of rapamycinVSMC differentiationContractile genesConsistent with in vitro findingsRapamycin treatmentCarotid artery injuryHuman coronary artery SMCsVascular smooth muscle cell differentiationIntimal hyperplasiaSmooth muscle cellsCoronary artery SMCsMTORC1 inhibitor rapamycinPhosphorylation of Smad2/3Inhibition of ALK5Smad-binding elementSmad transcription factorsALK5 activityArterial injuryArtery SMCsKnockout miceInhibition of mTORC1Vascular Smooth Muscle Cell PlasticityMuscle cells
2013
Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens
Lange M, Fujikawa T, Koulova A, Kang S, Griffin M, Lassaletta A, Erat A, Tobiash E, Bianchi C, Elmadhun N, Sellke F, Usheva A. Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens. Cell Cycle 2013, 13: 315-323. PMID: 24240190, PMCID: PMC3906247, DOI: 10.4161/cc.27056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ProliferationCoronary VesselsCulture Media, Serum-FreeCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p15Gene Knockdown TechniquesHumansMaleMammary ArteriesMitogensMyocytes, Smooth MusclePhosphorylationPrimary Cell CultureRetinoblastoma ProteinSerumSwineYY1 Transcription FactorConceptsCyclin-dependent kinase 2Internal mammary arteryCoronary artery SMCsDisease resistanceRb phosphorylationRetinoblastoma tumor suppressor proteinTumor suppressor proteinMammary arteryCoronary arteryCultured human cellsVascular smooth muscle cell responsesProtein speciesPhosphorylation profileSmooth muscle cell dedifferentiationSuppressor proteinPrevalence of restenosisKinase 2Serum stimulationMolecular mechanismsSmooth muscle cell responseMuscle cell dedifferentiationHuman cellsSMC populationCause of mortalitySiRNA knockdown
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