2018
The Cholinergic System as a Treatment Target for Opioid Use Disorder
Jensen KP, DeVito EE, Yip S, Carroll KM, Sofuoglu M. The Cholinergic System as a Treatment Target for Opioid Use Disorder. CNS Drugs 2018, 32: 981-996. PMID: 30259415, PMCID: PMC6314885, DOI: 10.1007/s40263-018-0572-y.Peer-Reviewed Original ResearchConceptsCholinergic systemUse disordersTreatment targetsOpioid use disorder epidemicCentral nervous system functionTreatment of OUDEffects of acetylcholineOpioid use disorderTobacco use disorderNervous system functionOpioid medicationsDegrade acetylcholineCurrent treatmentOpioid overdosesPreclinical studiesMedicationsAcetylcholineCholinesterase inhibitorsAlzheimer's diseaseNew treatmentsAccidental deathGlobal healthTreatmentOUDDisease
2016
Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine
Muise ED, Gandotra N, Tackett JJ, Bamdad MC, Cowles RA. Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine. Life Sciences 2016, 169: 6-10. PMID: 27866962, DOI: 10.1016/j.lfs.2016.10.030.Peer-Reviewed Original ResearchConceptsSmall intestineReceptor subtypesMuscarinic acetylcholine receptor subtypesShort bowel syndromeEffects of acetylcholineStem cell compartmentMuscarinic receptor subtypesAcetylcholine receptor subtypesSmall intestinal mucosaPotential therapeutic targetMurine small intestineCell compartmentSpecific mAChRBowel syndromeCholinergic pathwaysMyenteric plexusAnatomic distributionMuscarinic receptorsEntire alimentary tractIntestinal diseaseIntestinal mucosaEnterocyte turnoverIntestinal growthTherapeutic targetCrypt bases
2001
Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver
Hirata K, Nathanson M. Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Gastroenterology 2001, 121: 396-406. PMID: 11487549, DOI: 10.1053/gast.2001.26280.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetylcholineAngiogenesis InhibitorsAnimalsAnti-Inflammatory Agents, Non-SteroidalBicarbonatesBileBile DuctsBiological TransportCalciumCyclic AMPCyclosporineDose-Response Relationship, DrugEnzyme InhibitorsEpithelial CellsGlucagonHepatic ArteryHepatic VeinsIn Vitro TechniquesLiverMaleNitrobenzoatesortho-AminobenzoatesRatsRats, Sprague-DawleySecretinVasoconstrictor AgentsVasodilator AgentsVasopressinsConceptsBiliary bicarbonate excretionEffect of secretinBicarbonate excretionHepatic arteryBiliary bicarbonateNormal rat liverDiphenylamine-2-carboxylic acidBile ductPortal veinRat liverEffects of acetylcholineBile duct epitheliumDose-dependent fashionFormation of bileBile flowBlood supplyBicarbonate exchangeDuct epitheliumAcetylcholineArteryAbstractTextExcretionCyclosporin A.LiverCholangiocytes
1989
Effect of acetylcholine on membrane potential of cultured human nonpigmented ciliary epithelial cells.
Helbig H, Korbmacher C, Wohlfarth J, Coroneo M, Lindschau C, Quass P, Haller H, Coca-Prados M, Wiederholt M. Effect of acetylcholine on membrane potential of cultured human nonpigmented ciliary epithelial cells. Investigative Ophthalmology & Visual Science 1989, 30: 890-6. PMID: 2722445.Peer-Reviewed Original ResearchConceptsAcetylcholine-induced responsesCiliary epithelial cellsCytoplasmic Ca2Epithelial cellsEffects of acetylcholineAddition of acetylcholineMembrane potentialMobilization of Ca2M atropineRole of Ca2M acetylcholineMM quinidineChannel blockersFura-2Sustained depolarizationAcetylcholineIntracellular storesInitial hyperpolarizationTransient hyperpolarizationCell membrane potentialMicroelectrode techniquesCultured humanHyperpolarizationFree mediumOrigin-defective mutant
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