2025
The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes
Gui Y, Zhou G, Cui S, Li H, Lu H, Zhao H. The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes. Translational Psychiatry 2025, 15: 17. PMID: 39843917, PMCID: PMC11754786, DOI: 10.1038/s41398-025-03223-8.Peer-Reviewed Original ResearchConceptsLeft amygdala volumePolygenic risk scoresLeft amygdalaSex differencesBrain volumeMental disordersAmygdala volumeBrain anatomyEffect of polygenic risk scoresStudy of sex differencesExamined sex differencesPsychiatric Genomics ConsortiumMechanisms of sex differencesSex-specific genetic correlationsGenetic correlation analysisAmygdalaStructural MRI volumesSexually-dimorphicGenetic correlationsBrainDisordersRNA-seq dataGenomics ConsortiumCell-type compositionKnowledge of genetic basisThe effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers
Goldstein O, Shani S, Gana-Weisz M, Elkoshi N, Casey F, Sun Y, Chandratre K, Cedarbaum J, Blauwendraat C, Bar-Shira A, Thaler A, Gurevich T, Mirelman A, Giladi N, Orr-Urtreger A, Alcalay R. The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers. Journal Of Parkinson’s Disease 2025, 15: 291-299. PMID: 39973498, DOI: 10.1177/1877718x241310722.Peer-Reviewed Original ResearchPolygenic risk scoresPolygenic risk score modelPolygenic risk score associationsLRRK2 G2019S carriersGenetic risk factorsPD riskNon-carriersGenetic groupsDisease riskRisk scoreLRRK2 G2019SRisk factorsEffect of polygenic risk scoresGenetically complex conditionsCalculate polygenic risk scoresG2019S carriersElevated PRSAssessed PD riskAssociated with increased PD riskAshkenazi Jewish ancestryAssociated with PD riskModify disease riskGenotype callsGBA1 variantsLRRK2-G2019S-PD
2023
T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS
Zhang Y, Gülöksüz S, Stehouwer C, Greevenbroek M, Köhler S, Eussen S, Bosma H, Boxtel M, Schram M, Linden D, Rutten B, Blokland G. T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s169-s170. DOI: 10.1016/j.euroneuro.2023.08.303.Peer-Reviewed Original ResearchPolygenic risk scoresCognitive domainsCognitive functionHeritability of cognitive functionsEffect of polygenic risk scoresEnvironmental influencesThe Maastricht StudyPotential cognitive deficitsOverall cognitive functionBrain health indexImpact cognitive healthRisk factorsGenetic predispositionGene-environment interactionsCardio-metabolic diseasesLIBRA scoresNon-adjusted modelCognitive phenotypesCognitive deficitsCognitive performanceCognitive healthLifestyle factorsOverall cognitionBrain structuresMental health
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