1988
Glucocorticoids have a different action than aldosterone on target tissue
Halevy J, Boulpaep E, Budinger M, Binder H, Hayslett J. Glucocorticoids have a different action than aldosterone on target tissue. American Journal Of Physiology 1988, 254: f153-f158. PMID: 3337244, DOI: 10.1152/ajprenal.1988.254.1.f153.Peer-Reviewed Original ResearchConceptsRU 28362Same doseInhibitory actionDexamethasone-treated animalsBody wt-1Effects of glucocorticoidsEffect of dexamethasoneReceptor-independent actionsRat distal colonSodium channel blockersMarked inhibitory actionEquivalent short-circuit currentBasolateral potential differenceAldosterone receptorsEpithelial changesDistal colonChannel blockersAldosteroneSynthetic glucocorticoidDay 1WT-1Large intestineGlucocorticoidsEpithelial resistanceMarked inhibition
1982
Glucocorticoid-induced Insulin Resistance
F. J, Amatruda J. Glucocorticoid-induced Insulin Resistance. Journal Of Clinical Investigation 1982, 69: 866-875. PMID: 7042756, PMCID: PMC370141, DOI: 10.1172/jci110526.Peer-Reviewed Original ResearchConceptsAbility of insulinControl animalsInsulin bindingInsulin degradationDexamethasone treatmentNormal ratsInsulin receptorInsulin actionAminoisobutyrate uptakeWeight-matched control animalsGlucocorticoid-induced insulin resistancePrimary culturesAdministration of dexamethasoneDexamethasone-treated animalsPresence of hyperinsulinemiaEffect of insulinCellular insulin receptorsDose-response curveHepatocyte insulin receptorsSignificant hyperinsulinemiaInsulin resistanceAbsence of dexamethasoneLess insulinInsulin concentrationsVivo hyperinsulinemia
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