2025
BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments
Lahiri S, Hamilton G, Moore G, Goehring L, Huang T, Jensen R, Rothenberg E. BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments. Nature 2025, 640: 1103-1111. PMID: 40140565, PMCID: PMC12161360, DOI: 10.1038/s41586-025-08749-x.Peer-Reviewed Original ResearchConceptsRad51 filamentsFormation of Rad51 filamentsTumor suppressor protein BRCA2Resected single-stranded DNAHomology-directed DNA repairBRCA2 mutationsDNA strand exchangeBRCA2-deficient tumorsBRCA2-deficient cellsDouble-stranded DNA breaksSingle-stranded DNAQuantitative single-molecule localization microscopySingle-molecule approachesStrand exchangeDNA substratesBRCA2 deficiencyCellular contextFilament stabilityDNA repairResponse to PARPiRAD51Sensitivity to PARPiDNA breaksBRCA2PARP1 inhibition
2024
Disruption of mitochondrial unfolded protein response results in telomere shortening in mouse oocytes and somatic cells
Cozzolino M, Ergun Y, Ristori E, Garg A, Imamoglu G, Seli E. Disruption of mitochondrial unfolded protein response results in telomere shortening in mouse oocytes and somatic cells. Aging 2024, 16: 2047-2060. PMID: 38349865, PMCID: PMC10911389, DOI: 10.18632/aging.205543.Peer-Reviewed Original ResearchConceptsCaseinolytic peptidase PMitochondrial unfolded protein responseUnfolded protein responseTelomere integrityProtein responseGermline deletionSomatic cellsSomatic agingSomatic cell divisionDouble-stranded DNA breaksAged miceTelomere shorteningAssociated with cellular senescenceTelomeric regionsProtein homeostasisAccelerated follicular depletionChromosome stabilityCell divisionMtUPRDNA breaksTelomereAging phenotypesCellular senescenceFollicular depletionMouse oocytes
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