BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments
Lahiri S, Hamilton G, Moore G, Goehring L, Huang T, Jensen R, Rothenberg E. BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments. Nature 2025, 640: 1103-1111. PMID: 40140565, PMCID: PMC12161360, DOI: 10.1038/s41586-025-08749-x.Peer-Reviewed Original ResearchConceptsRad51 filamentsFormation of Rad51 filamentsTumor suppressor protein BRCA2Resected single-stranded DNAHomology-directed DNA repairBRCA2 mutationsDNA strand exchangeBRCA2-deficient tumorsBRCA2-deficient cellsDouble-stranded DNA breaksSingle-stranded DNAQuantitative single-molecule localization microscopySingle-molecule approachesStrand exchangeDNA substratesBRCA2 deficiencyCellular contextFilament stabilityDNA repairResponse to PARPiRAD51Sensitivity to PARPiDNA breaksBRCA2PARP1 inhibition
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