Clinical and molecular characterization of patients with cancer of unknown primary in the modern era
Varghese A, Arora A, Capanu M, Camacho N, Won H, Zehir A, Gao J, Chakravarty D, Schultz N, Klimstra D, Ladanyi M, Hyman D, Solit D, Berger M, Saltz L. Clinical and molecular characterization of patients with cancer of unknown primary in the modern era. Annals Of Oncology 2017, 28: 3015-3021. PMID: 29045506, PMCID: PMC5834064, DOI: 10.1093/annonc/mdx545.Peer-Reviewed Original ResearchConceptsNext-generation sequencingOverall survivalCUP patientsTargeted therapyPattern of metastatic spreadTargeted Next-Generation SequencingMedian overall survivalMolecular characterization of patientsDiagnosis of CUPInstitutional review board approvalTargetable genomic alterationsTumor molecular profilingDominant mutational signatureTreatment of patientsReview board approvalCharacterization of patientsClinical trial enrollmentDocument demographic informationCytotoxic chemotherapyDismal prognosisMetastatic spreadDescription of patientsPathological evaluationClinical outcomesBoard approval
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