2024
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells.
Williams A, Siniscalco E, Grassmann J, Craft J, Eisenbarth S, Uthaman G. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. The Journal Of Immunology 2024, 212: 0620_4120-0620_4120. DOI: 10.4049/jimmunol.212.supp.0620.4120.Peer-Reviewed Original ResearchPeanut-specific IgET cellsSpecific IgEFood allergyT Follicular Helper CellsCD4+ T cellsDOCK8-deficient patientsFood-specific IgEPeanut-specific IgE.Human T cellsCells in vitroDifferentiation in vivoSevere food allergyTfh cellsRegulatory populationsOvercome toleranceHelper cellsDeficient patientsSpecific IgE.DOCK8IgE productionSTAT3 mutationsMiceCholera toxinIgE
2017
Single-cell analysis of CCR6+ human Th cells reveals varying degrees of the type-17 phenotype, ranging from cells co-expressing to those fully suppressing opposing pathways
Singh S, Edara N, Zhang H, Chen J, Farber J. Single-cell analysis of CCR6+ human Th cells reveals varying degrees of the type-17 phenotype, ranging from cells co-expressing to those fully suppressing opposing pathways. The Journal Of Immunology 2017, 198: 150.14-150.14. DOI: 10.4049/jimmunol.198.supp.150.14.Peer-Reviewed Original ResearchType 17Co-expressionLineage-specific genesCo-expressed genesCells expressing various levelsTh cellsExpression of genesPattern of expressionSingle-cell analysisExpression of CCR6Opposing pathwaysMulti-lineage cellsGenesHuman Th cellsCells co-expressingLineagesDifferentiation in vivoCell sortingCCR6 expressionExpression levelsMemory populationIL-22IL-17A/FRT-PCRCCR6
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