2024
Current understanding and new insights in the treatment of IgA nephropathy
Zhang Y, Zhang H. Current understanding and new insights in the treatment of IgA nephropathy. Nephrology 2024, 29: 75-79. PMID: 38958055, DOI: 10.1111/nep.14340.Peer-Reviewed Original ResearchIgA nephropathyProgression to end-stage kidney diseaseRisk of progression to end-stage kidney diseaseTreatment of IgA nephropathyEra of targeted treatmentCurrent treatment strategiesEnd-stage kidney diseaseDownstream complement activationDevelopment of IgANRandomized Controlled TrialsImmunosuppressive approachesPotential therapeutic targetPrimary glomerulonephritisKDIGO guidelinesOff-labelTreatment strategiesKidney diseaseIgANPathogenic mechanismsControlled TrialsTreatment approachesComplement activationDisease pathogenesisTherapeutic targetNephropathyCombined Genetic Association and Differed Expression Analysis of UBE2L3 Uncovers a Genetic Regulatory Role of (Immuno)proteasome in IgA Nephropathy
Xu L, Gan T, Li Y, Chen P, Shi S, Liu L, Lv J, Zhang H, Zhou X. Combined Genetic Association and Differed Expression Analysis of UBE2L3 Uncovers a Genetic Regulatory Role of (Immuno)proteasome in IgA Nephropathy. Kidney Diseases 2024, 10: 167-180. PMID: 38835407, PMCID: PMC11149991, DOI: 10.1159/000537987.Peer-Reviewed Original ResearchGd-IgA1IgA nephropathyHealthy controlsProteasome subunitsLevels of Gd-IgA1Genetic associationPeripheral blood mononuclear cellsExpression levelsEnd-stage renal diseaseSusceptibility to IgANBlood mononuclear cellsGd-IgA1 productionImmune cell typesBlood mRNA levelsFollow-up dataGalactose-deficient IgA1Cell typesUbiquitin-proteasome systemProcess of glycosylationPathogenesis of IgANAssociation of variantsDevelopment of IgANHigher proteinuriaLow eGFRHighest expression level
2023
An Update on the Genetics of IgA Nephropathy
Xu L, Zhou X, Zhang H. An Update on the Genetics of IgA Nephropathy. Journal Of Clinical Medicine 2023, 13: 123. PMID: 38202130, PMCID: PMC10780034, DOI: 10.3390/jcm13010123.Peer-Reviewed Original ResearchGenome-wide association studiesWhole-genome sequencingEnd-stage kidney diseaseCandidate causal variantsNext-generation sequencing technologiesInvolvement of epigeneticsPathogenesis of IgANFine-mapping studiesPathogenic molecular pathwaysGenetic architectureSequencing technologiesCausal variantsRisk lociAssociation studiesGenetic studiesNew potential therapeutic targetsMolecular pathwaysImmunoglobulin A (IgA) nephropathyPhenotypic variabilityPotential pathogenic mechanismsDevelopment of IgANPotential therapeutic targetComplexity of pathogenesisLinkage studiesExome sequencing
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