2024
VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Wolf M, Madden M, Arner E, Bader J, Ye X, Vlach L, Tigue M, Landis M, Jonker P, Hatem Z, Steiner K, Gaines D, Reinfeld B, Hathaway E, Xin F, Tantawy M, Haake S, Jonasch E, Muir A, Weiss V, Beckermann K, Rathmell W, Rathmell J. VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis. Journal Of Clinical Investigation 2024, 134: e173934. PMID: 38618956, PMCID: PMC11014672, DOI: 10.1172/jci173934.Peer-Reviewed Original ResearchConceptsClear cell renal cell carcinomaTumor-associated macrophagesVon Hippel-LindauImmune landscapeTumor microenvironmentVon Hippel-Lindau lossVHL-KOImmune cellsAnti-programmed cell death 1VHL lossInflammatory transcriptional signaturesTumor immune landscapeCell death 1Cell renal cell carcinomaRenal cell carcinomaHuman ccRCC tumorsTreatment of clear cell renal cell carcinomaMyeloid microenvironmentDeath-1RENCA modelCell carcinomaCcRCC tumorsLymphoid cellsChemokine CX3CL1Renal tumorigenesis
2011
Fine balance between HIF1 and HIF2 in smooth muscle is crucial for normal development and survival
Lei L, Liu D, Jiang W, Huang Y, Giordano F. Fine balance between HIF1 and HIF2 in smooth muscle is crucial for normal development and survival. The FASEB Journal 2011, 25: 616.10-616.10. DOI: 10.1096/fasebj.25.1_supplement.616.10.Peer-Reviewed Original ResearchSmooth muscle cellsVon Hippel-LindauSmooth muscleDied of heart failureDeletion of von Hippel-LindauDouble knockoutVascular smooth muscle cellsMicro-CT angiographyNormal developmentEmbryonic lethalityApparent etiologyMidline defectsFetal developmentVascular reactivityEctopia cordisE14.5-15.5Heart failureMuscle cellsVascular spasmIntramyocardial hematomaVascular perfusionMiceGastroschisisVascular segmentsMicro-CT
2006
Lipid-Rich Variant of Pancreatic Endocrine Neoplasms
Singh R, Basturk O, Klimstra D, Zamboni G, Chetty R, Hussain S, La Rosa S, Yilmaz A, Capelli P, Capella C, Cheng J, Adsay N. Lipid-Rich Variant of Pancreatic Endocrine Neoplasms. The American Journal Of Surgical Pathology 2006, 30: 194-200. PMID: 16434893, DOI: 10.1097/01.pas.0000184819.71752.ad.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdrenocortical CarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Renal CellDiagnosis, DifferentialEndocrine Gland NeoplasmsFemaleHumansImmunohistochemistryLipidsMaleMicroscopy, Electron, TransmissionMiddle AgedMultiple Endocrine Neoplasia Type 1Pancreatic Neoplasmsvon Hippel-Lindau DiseaseConceptsPancreatic endocrine neoplasmsDiagnostic challengeCytologic diagnosis of adenocarcinomaNeedle aspiration cytology diagnosisLipid-rich tumorsAdrenal cortical carcinomaSolid pseudopapillary tumorDiagnosis of adenocarcinomaRenal cell carcinomaAdrenal cortical cellsVon Hippel-LindauCortical carcinomaCell carcinomaClinicopathological characteristicsPathology reportsMicrovesicular cytoplasmMelan-ASurgical pathologistsEndocrine neoplasmsEndocrine morphologyHIF-1alphaChromatin patternDelicate vasculatureElderly malesBiopsy
2002
Mutations in the VHL gene in sporadic apparently congenital polycythemia
Pastore Y, Jelinek J, Ang S, Guan Y, Liu E, Jedlickova K, Krishnamurti L, Prchal J. Mutations in the VHL gene in sporadic apparently congenital polycythemia. Blood 2002, 101: 1591-1595. PMID: 12393546, DOI: 10.1182/blood-2002-06-1843.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArginineAspartic AcidBase SequenceChildChild, PreschoolDNA Mutational AnalysisErythroid Precursor CellsErythropoietinFemaleHeterozygoteHomozygoteHumansLeucineLigasesMaleMutationPedigreePolycythemiaSequence Analysis, DNATryptophanTumor Suppressor ProteinsTyrosineUbiquitin-Protein LigasesValineVon Hippel-Lindau Tumor Suppressor ProteinConceptsVon Hippel-LindauVHL geneTumor suppressor von Hippel-LindauPolycythemic disordersDownstream target genesVHL mutationsHypoxia-sensing pathwayVHL functionHypoxia-inducible factor-1alphaProteosomal degradationTarget genesErythroid cellsGermline VHL mutationsCongenital polycythemiaChuvash polycythemiaVHL syndromeGenesHIF-1alphaDevelopment of tumorsFactor-1alphaElevated serum Epo levelsMutationsEPO productionAutosomal dominant disorderPathway
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