Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study
Zhang Y, Zeng Q, Belfer I, Goel R, Porter M, Chu Y, Barst R, Hassell K, Machado R, Goldsmith J, Gladwin M, Krishnamurti L. Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study. Blood 2011, 118: 1075. DOI: 10.1182/blood.v118.21.1075.1075.Peer-Reviewed Original ResearchSickle cell diseaseAcute pain crisisChronic painPain crisisPain phenotypesPain rateSCD painSevere painPain sensitivitySingle nucleotide polymorphismsAG genotype carriersChronic pain ratesSickle cell anemia patientsType of painAfrican American patientsGenetic factorsDescription of painLogistic regression analysisLower pain sensitivityCOMT genetic variantsChi-square testMultinomial logistic regression analysisCatechol-O-methyl transferase (COMT) genePain episodesMild painUnderstanding the cancer pain experience in American Indians of the Northern Plains
Haozous EA, Knobf MT, Brant JM. Understanding the cancer pain experience in American Indians of the Northern Plains. Psycho-Oncology 2011, 20: 404-410. PMID: 20878836, DOI: 10.1002/pon.1741.Peer-Reviewed Original ResearchConceptsCancer painDistrust of outsidersBrief Pain Inventory-Short FormAmerican IndiansSemi-structured interviewsAverage pain scoreDescription of painTime of interviewCancer pain experienceDominant themesNeuropathic painPain scoresModerate painCultural groupsPain managementEnjoyment of lifePain interventionsAI patientsHematologic malignanciesPsychosocial distressPainPain experienceQualitative descriptive studyFeelings of guiltDescriptive study
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