2019
Identification of genetic variations in Necator americanus through resequencing by whole genome amplification
Liu Y, Liu H, Xie Y, Zhang B, Zou X, Ou M, Ye X, Han Y, Wu J, Chen X, Dong S, Zhu K, Guo C, Wang P, Zhai H, Jing C, Yang G. Identification of genetic variations in Necator americanus through resequencing by whole genome amplification. Journal Of International Medical Research 2019, 47: 4353-4364. PMID: 31331217, PMCID: PMC6753555, DOI: 10.1177/0300060519862069.Peer-Reviewed Original ResearchConceptsWhole-genome resequencingSingle nucleotide polymorphismsGenome resequencingGenetic variationParasite genome sequencesDe novo genome assemblyMost single nucleotide polymorphismsGene ontology analysisNovo genome assemblyMultiple displacement amplification (MDA) methodCommon drug targetsWhole genome amplificationGenome assemblyOntology analysisReference genomeGenome sequenceGO analysisSequencing readsDrug targetsGenome amplificationSmall parasitesNucleotide polymorphismsParasite samplesGenotype probabilitiesResequencing
2016
De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
Sistrom M, Evans B, Benoit J, Balmer O, Aksoy S, Caccone A. De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. PLOS ONE 2016, 11: e0147660. PMID: 26910229, PMCID: PMC4766357, DOI: 10.1371/journal.pone.0147660.Peer-Reviewed Original ResearchConceptsGenome assemblyGenetic recombinationT. bruceiPentatricopeptide repeat-containing proteinGenome-wide similarityDe novo genome assemblyHybrid de novo assemblyComparative genomic analysisRepeat-containing proteinVariant surface glycoprotein (VSG) coatComplete genome assemblyDe novo assemblyNovo genome assemblyGenomic differentiationSignificant epidemiological consequencesWhole-genome sequencingGene familyPutative genesEukaryotic pathogensNovo assemblySerum resistance associated geneHuman infective strainsGenomic analysisSingle geneAlcohol oxidoreductase
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