2025
Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity
Sawyer A, Vaca C, Malik N, Clerc I, Craft J, Hudson H, Scholtés G, Schiltz G, Roh M, Song C, D’Aquila R. Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity. Viruses 2025, 17: 514. PMID: 40284957, PMCID: PMC12031279, DOI: 10.3390/v17040514.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusDecreased HIV-1 infectivitySpread of human immunodeficiency virusLevels of A3GHIV-producing cellsHIV-1 infectionA3GDecreased viral infectivityDegradation of A3GDegradation of APOBEC3GResistance-conferring mutationsInfectivity of virionsAnti-HIV therapeuticsViral infectivity factorImmunodeficiency virusCell-intrinsic defenseViral infectionAPOBEC3GCatalytic polypeptide-like 3Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3Infectivity factorInfectionA3G/FVifViral proteins
2024
DNAR-16. TARGETING APOBEC CYTIDINE DEAMINASES TO ENHANCE RADIOSENSITIVITY IN GLIOMA
Marin B, Gujar A, Kocakavuk E, Johnson K, Amin S, Verhaak R. DNAR-16. TARGETING APOBEC CYTIDINE DEAMINASES TO ENHANCE RADIOSENSITIVITY IN GLIOMA. Neuro-Oncology 2024, 26: viii120-viii121. PMCID: PMC11553289, DOI: 10.1093/neuonc/noae165.0467.Peer-Reviewed Original ResearchApolipoprotein B mRNA-editing enzyme catalytic polypeptide-likeRadiation therapyNon-Homologous End JoiningRecurrent gliomaDNA-dependent protein kinaseMutational signaturesRT-induced DNA damageMonitoring response to treatmentRadiosensitivity in vitroEnhanced radiosensitivity in vitroA3GPromote tumor evolutionResponse to treatmentAutophosphorylation of DNA-dependent protein kinaseAPOBEC mutational signaturesAdult brain tumorsPrimary adult brain tumorGlioma Longitudinal Analysis ConsortiumFamily of cytidine deaminasesRadiosensitizing gliomasAPOBEC3G (A3GNon-homologous end-joining pathwayPost-RTGlioma cell linesWhole-genome sequencing
2019
APOBEC3A Loop 1 Is a Determinant for Single-Stranded DNA Binding and Deamination
Ziegler SJ, Hu Y, Devarkar SC, Xiong Y. APOBEC3A Loop 1 Is a Determinant for Single-Stranded DNA Binding and Deamination. Biochemistry 2019, 58: 3838-3847. PMID: 31448897, PMCID: PMC7211764, DOI: 10.1021/acs.biochem.9b00394.Peer-Reviewed Original ResearchConceptsSubstrate specificityLoop 1A3 proteinsRecent structural studiesBase editing technologyEnzyme catalytic polypeptideProtein functionSubstrate recognitionDNA bindingEditing technologySsDNA recognitionSubstrate selectionNovel CRISPRDeamination activityApolipoprotein B mRNACatalytic polypeptideBiochemical levelBase editorsLoop regionInnate immune systemProteinA3ADeaminase activityA3GA3 family
2007
Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif
Xiao Z, Xiong Y, Zhang W, Tan L, Ehrlich E, Guo D, Yu X. Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif. Journal Of Molecular Biology 2007, 373: 541-550. PMID: 17869271, DOI: 10.1016/j.jmb.2007.07.029.Peer-Reviewed Original ResearchConceptsVif functionHCCH motifA3GPotential new targetsA3G degradationE3 ubiquitin ligaseUbiquitin-proteasome machineryHIV-1 VifAnti-viral drug developmentBC boxCul5 boxUbiquitin ligaseNovel motifProteasomal degradationCys residuesNew targetsDrug developmentMotifCullin5ResiduesStructural requirementsVif
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