Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity
Sawyer A, Vaca C, Malik N, Clerc I, Craft J, Hudson H, Scholtés G, Schiltz G, Roh M, Song C, D’Aquila R. Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity. Viruses 2025, 17: 514. PMID: 40284957, PMCID: PMC12031279, DOI: 10.3390/v17040514.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusDecreased HIV-1 infectivitySpread of human immunodeficiency virusLevels of A3GHIV-producing cellsHIV-1 infectionA3GDecreased viral infectivityDegradation of A3GDegradation of APOBEC3GResistance-conferring mutationsInfectivity of virionsAnti-HIV therapeuticsViral infectivity factorImmunodeficiency virusCell-intrinsic defenseViral infectionAPOBEC3GCatalytic polypeptide-like 3Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3Infectivity factorInfectionA3G/FVifViral proteins
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