2024
Epigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder
Tang L, Zhao P, Pan C, Song Y, Zheng J, Zhu R, Wang F, Tang Y. Epigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder. Journal Of Affective Disorders 2024, 363: 249-257. PMID: 39029702, DOI: 10.1016/j.jad.2024.07.110.Peer-Reviewed Original ResearchMajor depressive disorderMajor depressive disorder patientsStructural-functional connectivityHPA axisDepressive disorderIncreased susceptibility to MDDSusceptibility to major depressive disorderMajor depressive disorder treatmentHealthy controlsStress-related disordersBrain network dynamicsMultimodal neuroimaging dataGender-matched healthy controlsSubcortical regionsNeuroimaging dataChronic stressCortical regionsNodal levelMedical statusFunctional networksCRHR1FKBP5CpG sitesDisordersMolecular underpinnings
2013
Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults
White S, Acierno R, Ruggiero KJ, Koenen KC, Kilpatrick DG, Galea S, Gelernter J, Williamson V, McMichael O, Vladimirov VI, Amstadter AB. Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults. Journal Of Anxiety Disorders 2013, 27: 678-683. PMID: 24077033, PMCID: PMC4182958, DOI: 10.1016/j.janxdis.2013.08.003.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPTSD symptomsHormone receptor 1 geneCorticotropin-releasing hormone receptor 1 (CRHR1) geneSingle nucleotide polymorphismsReceptor 1 geneCRHR1 variationEtiology of PTSDHPA axisAdrenal axisCRHR1 variantsPosttraumatic stress symptomsStress disorderAnxiety disordersFinal analysisSymptomsHeritable anxiety disordersEuropean-American subsampleAdultsStress symptomsCRHR1Genetic variantsMultiple testingDiagnosisDisorders
2011
A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African‐American women
Kranzler HR, Feinn R, Nelson EC, Covault J, Anton RF, Farrer L, Gelernter J. A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African‐American women. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 960-968. PMID: 21998007, PMCID: PMC3227028, DOI: 10.1002/ajmg.b.31243.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol DrinkingBlack or African AmericanChildChild AbuseDepressionDepressive Disorder, MajorFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHumansMiddle AgedPolymorphism, Single NucleotideReceptors, Corticotropin-Releasing HormoneStress, PsychologicalSubstance-Related DisordersConceptsMajor depressive episodeAdverse childhood experiencesRisk of depressionTAT haplotypeAlcohol dependenceDepressive episodeLifetime riskAA womenCorticotropin-releasing hormone type 1 receptorOdds of MDERisk of MDELifetime substance use disorderType 1 receptorSubstance use disordersAfrican AmericansAfrican American womenChildhood experiencesDepression riskThree-SNP haplotypeAD riskUse disordersAdult depressionAlcohol consumptionCRHR1 haplotypeCRHR1
2010
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12 566 individuals
Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Consortium I, Barcellos L. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12 566 individuals. Human Molecular Genetics 2010, 19: 4286-4295. PMID: 20699326, PMCID: PMC2951862, DOI: 10.1093/hmg/ddq328.Peer-Reviewed Original ResearchConceptsMultiple sclerosisMS casesHealthy controlsCRHR1 variantsCorticotrophin-releasing hormone receptor 1Primary genetic risk factorAdrenal (HPA) axis genesHPA axis regulationGenetic risk factorsHormone receptor 1European ancestryMS pathogenesisSystem involvementRisk factorsUnivariate analysisAxis regulationReceptor 1Axis genesStrong associationCRHR1Lines of evidenceSclerosisDiscovery datasetImportant predictorFurther investigation
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