Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation
Falk E, Norman K, Garkun Y, Demars M, Im S, Taccheri G, Short J, Caro K, McCraney S, Cho C, Smith M, Lin H, Koike H, Bateh J, Maccario P, Waltrip L, Janis M, Morishita H. Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation. Science Advances 2021, 7: eabe1527. PMID: 33674307, PMCID: PMC7935362, DOI: 10.1126/sciadv.abe1527.Peer-Reviewed Original ResearchConceptsFrontal neuronsModel of fragile X syndromeMouse model of fragile X syndromeNicotinic cholinergic systemTop-down neuronsTreating cognitive deficitsBehavior in adulthoodNicotinic signalingCircuit maturationFragile X syndromeNicotine regulationCholinergic inputMouse modelIncreased expressionCognitive deficitsCortex developmentCholinergic systemCognitive functionTop-down projectionsX syndromeNeurodevelopmental disordersNeuronsVisual cortexAdolescentsMaturation process
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