2025
Infection-relevant conditions dictate differential versus coordinate expression of Salmonella chaperones and cochaperones
Chan C, Mukai K, Groisman E. Infection-relevant conditions dictate differential versus coordinate expression of Salmonella chaperones and cochaperones. MBio 2025, 16: e00227-25. PMID: 40162747, PMCID: PMC12077118, DOI: 10.1128/mbio.00227-25.Peer-Reviewed Original ResearchConceptsInfection-relevant conditionsJ-domainProtein homeostasisChaperone DnaKCytoplasmic MgMolecular chaperonesNucleotide exchange factor GrpEChaperone trigger factorSigma factor RpoHProteins co-translationallyExpression of molecular chaperonesPreventing protein aggregationIncreased mRNA amountsPerturb protein homeostasisMRNA amountsCochaperone DnaJRpoH proteinCo-translationallyPost-translationallyCochaperoneExpressed genesFolded proteinsDnaKCoordinated expressionChaperone
2024
Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis
Li Y, Xu W, Cheng Y, Djenoune L, Zhuang C, Cox A, Britto C, Yuan S, Wang S, Sun Z. Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2402818121. PMID: 39541357, PMCID: PMC11588059, DOI: 10.1073/pnas.2402818121.Peer-Reviewed Original ResearchConceptsDynein axonemal assembly factorsAssembly factorsCytosolic fociOuter dynein armsMacromolecular machinesAxonemal dyneinsAssembly hubDynein armsMolecular condensateLiquid-liquid phase separationCochaperoneEncoding mRNAFoci formationCiliary motilityStable interactionLRRC6Functional significanceRUVBL1DyneinMRNAAssembly of multiple componentsAssemblyPotential mechanismsRUVBL2Biogenesis
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