2024
Kv1.3 regulation of brain immune function in vitro and in vivo
Bowen C, Nguyen H, Lin Y, Bagchi P, Natu A, Xiao H, Espinosa‐Garcia C, Kumar P, Wulff H, Seyfried N, Rangaraju S. Kv1.3 regulation of brain immune function in vitro and in vivo. Alzheimer's & Dementia 2024, 20: e093042. PMCID: PMC11709668, DOI: 10.1002/alz.093042.Peer-Reviewed Original ResearchProtein processingN-terminusProximity-based proteomicsProtein-protein interactomePDZ-binding motifPDZ-binding domainPlasma membrane proteinsDeletion in vivoJurkat T cellsT cellsKO miceBiotin ligaseCMV-Cre miceRNA-seqTrafficking proteinsBiotinylated proteinsTranscriptome levelC-terminusMembrane proteinsInteractorsMicroglial signatureImmune signalingPlasma membraneLPS stimulationDifferential expression
2023
Immune regulatory roles for Kv1.3 channels in Microglia in Alzheimer’s Disease
Bowen C, Lin Y, Zeng H, Nguyen H, Xiao H, Kumar P, Duong D, Espinosa‐Garcia C, Wulff H, Seyfried N, Rangaraju S. Immune regulatory roles for Kv1.3 channels in Microglia in Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.078851.Peer-Reviewed Original ResearchKv1.3 blockadeKv1.3 channelsKv1.3 blockersMouse model of AD pathologyBlockade of Kv1.3Immune regulatory roleWestern blottingAlzheimer's diseaseCMV-Cre miceChannels in vitroPDZ-binding motifPlasma membrane proteinsInhibition in vivoCell type-specificPharmacological blockadeOlder 5XFAD miceCMV-CreFunction of microgliaChannel abundanceKv1.3Mouse modelBiotin ligaseFlow cytometryTrafficking proteinsBiotinylated proteins
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply