2019
20 The Need for Speed: Adjunctive Triple Chronotherapy in the Accelerated Treatment of Acute Depression and Suicidality in the Adolescent Population
Hurd D, Arzubi E, Herrera M, Coombs N, Brant J. 20 The Need for Speed: Adjunctive Triple Chronotherapy in the Accelerated Treatment of Acute Depression and Suicidality in the Adolescent Population. CNS Spectrums 2019, 24: 183-184. DOI: 10.1017/s1092852919000142.Peer-Reviewed Original ResearchTriple chronotherapyAcute depressionAdolescent populationSecondary outcomesPilot studySeverity of illnessHAMD-17 scoresBright light therapyAdjunctive treatmentPrimary outcomeAdjunctive interventionSevere depressionLight therapyDepressive symptomsSleep deprivationDepressionAccelerated treatmentSuicidalityInterventionOutcomesTreatmentChronotherapyScoresSignificant improvementAdolescents
2009
Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB
Selvaraj S, Venkatesha Murthy N, Bhagwagar Z, Bose SK, Hinz R, Grasby PM, Cowen PJ. Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. Psychopharmacology 2009, 213: 555-562. PMID: 19756523, DOI: 10.1007/s00213-009-1660-y.Peer-Reviewed Original ResearchConceptsPositron emission tomography studyEmission tomography studiesDepressed patientsHealthy controlsMajor depressionMedication-free depressed patientsPoor long-term prognosisPrevious positron emission tomography (PET) studiesTomography studyLong-term prognosisAnterior cingulate cortexPositron emission tomographyBrain stemMean durationSerotonin neurotransmissionAcute depressionFrontal cortexPatientsCingulate cortexState markerBrain regionsEmission tomographyConclusionsThese resultsBrainDepression
2005
Increased salivary cortisol after waking in depression
Bhagwagar Z, Hafizi S, Cowen P. Increased salivary cortisol after waking in depression. Psychopharmacology 2005, 182: 54-57. PMID: 15991000, DOI: 10.1007/s00213-005-0062-z.Peer-Reviewed Original ResearchConceptsSalivary cortisolMedication-free subjectsMorning cortisol secretionCommunity-based sampleExaggerated releaseCortisol secretionAcute depressionHealthy controlsMajor depressionCortisol levelsDepressed subjectsCortisolMore cortisolDepressionPatientsRecent studiesSubjectsHypersecretionPathophysiologyObjectiveToMinMethodsWeResultsInControlSecretion
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