2022
Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice
Goedeke L, Murt KN, Di Francesco A, Camporez JP, Nasiri AR, Wang Y, Zhang X, Cline GW, de Cabo R, Shulman GI. Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice. Aging Cell 2022, 21: e13539. PMID: 35088525, PMCID: PMC8844126, DOI: 10.1111/acel.13539.Peer-Reviewed Original ResearchConceptsControlled-release mitochondrial protonophoreAge-related metabolic diseasesHepatocellular carcinomaMetabolic diseasesHigh-fat diet-fed miceProtein kinase C epsilon activationDiet-induced obese miceWhole-body energy expenditureC57BL/6J male miceDiet-fed miceHigh-fat dietHepatic lipid peroxidationHepatic lipid contentMitochondrial uncouplingHepatic insulin resistanceHigh therapeutic indexHepatic mitochondrial biogenesisStrain-specific effectsSex-specific mannerCRMP treatmentHFD feedingUnwanted side effectsObese miceInsulin resistanceChronic ingestion
2017
2092
Gruenbaum S, Dhaher R, Rapuano A, Eid T. 2092. Journal Of Clinical And Translational Science 2017, 1: 56-56. PMCID: PMC6798929, DOI: 10.1017/cts.2017.200.Peer-Reviewed Original ResearchTemporal lobe epilepsyDays of drinkingDentate hilusBCAA groupNeuronal viabilityControl groupHilar neuron lossHilar neuronal lossRight dentate gyrusRelevant rodent modelsRole of BCAABCAA ingestionNeuronal lossSpontaneous seizuresLobe epilepsyNeuron lossSeizure activityChronic ingestionDentate gyrusInfusion siteHilar regionRodent modelsMethionine sulfoximineNeurochemical modulationRats
1999
Review article: nonsteroidal anti‐inflammatory drug‐associated gastrointestinal complications—guidelines for prevention and treatment
Schoenfeld, Kimmey, Scheiman, Bjorkman, Laine. Review article: nonsteroidal anti‐inflammatory drug‐associated gastrointestinal complications—guidelines for prevention and treatment. Alimentary Pharmacology & Therapeutics 1999, 13: 1273-1285. PMID: 10540041, DOI: 10.1046/j.1365-2036.1999.00617.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastrointestinal complicationsPylori infectionSerious gastrointestinal complicationsH. pylori infectionHelicobacter pylori infectionProton pump inhibitorsLowest possible dosagePotential of treatmentNSAID therapyNSAID useAnalgesic therapyCorticosteroid useGastrointestinal bleedingUlcer diseaseAntisecretory agentsPump inhibitorsChronic ingestionPain relieversNSAIDsComplicationsPatientsExact associationPossible dosageRoutine testingPast history
1994
Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus
Trevisan L, Fitzgerald L, Brose N, Gasic G, Heinemann S, Duman R, Nestler E. Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus. Journal Of Neurochemistry 1994, 62: 1635-1638. PMID: 8133290, DOI: 10.1046/j.1471-4159.1994.62041635.x.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureSubunit immunoreactivityEthanol exposureGlutamate receptorsIsoxazole propionic acid (AMPA) glutamate receptorsPropionic acid glutamate receptorsImportant neurochemical substrateReceptor subunit immunoreactivityGlutamate receptor subunit 1Different neurotransmitter systemsAspartate glutamate receptorsDifferent pharmacological profilesReceptor subunit 1Effects of ethanolChronic administrationChronic treatmentNMDAR1 immunoreactivityCerebral cortexChronic ingestionEthanol dependenceGluR2 proteinRat hippocampusNeurotransmitter systemsNMDAR1 subunitNucleus accumbens
1974
Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites
Russell R, Boyer J, Bagheri S, Hruban Z. Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites. New England Journal Of Medicine 1974, 291: 435-440. PMID: 4843409, DOI: 10.1056/nejm197408292910903.Peer-Reviewed Original ResearchMeSH KeywordsAscitesBasement MembraneBiopsy, NeedleChemical and Drug Induced Liver InjuryCollagenFemaleHepatic VeinsHistocytochemistryHumansHypertension, PortalLipid MetabolismLiverLiver CirculationLiver CirrhosisMaleMicroscopy, ElectronMicroscopy, FluorescenceMiddle AgedSclerosisTime FactorsVitamin AConceptsPortal hypertensionHepatic blood flowChronic hypervitaminosis ALiver biopsy materialLipid storage cellsChronic hypervitaminosisFocal congestionVein sclerosisHepatic injuryPerisinusoidal fibrosisHypervitaminosis AChronic ingestionHepatic functionClinical signsHistologic examinationBlood flowUnusual lesionFrozen sectionsIto cellsPerisinusoidal spaceCirrhosisHypertensionAscitesVitaminLike material
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