2023
ATR protects centromere identity by promoting DAXX association with PML nuclear bodies
Trier I, Black E, Joo Y, Kabeche L. ATR protects centromere identity by promoting DAXX association with PML nuclear bodies. Cell Reports 2023, 42: 112495. PMID: 37163376, DOI: 10.1016/j.celrep.2023.112495.Peer-Reviewed Original ResearchConceptsCentromere identityInterphase centromeresNuclear bodiesDNA damage-independent mannerPromyelocytic leukemia nuclear bodiesMitotic chromosome segregationCentromere protein AATR inhibitionDNA damage responsePML nuclear bodiesATR-dependent phosphorylationAcute ATR inhibitionChaperone DAXXGenome stabilityChromosome segregationPML-NBsDamage responseUnperturbed cellsMaster regulatorAtaxia telangiectasiaC-terminusFormation defectsCentromeresCENPAberrant increase
2017
A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
Kabeche L, Nguyen HD, Buisson R, Zou L. A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation. Science 2017, 359: 108-114. PMID: 29170278, PMCID: PMC5875943, DOI: 10.1126/science.aan6490.Peer-Reviewed Original ResearchConceptsFaithful chromosome segregationChromosome segregationR-loopsATR pathwayCyclin-dependent kinase 1 (CDK1) activityWhole chromosome missegregationReplication stress responseReplication protein ADNA damage responseCentromere protein FKinase 1 activityATR functionAurora BDamage responseChromosome instabilityCentromeresProtein FAtaxia telangiectasiaAurora AUnexpected roleStress responseDNA damageDNA synthesisATRProtein A
2014
Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase
Sau S, Sutradhar S, Paul R, Sinha P. Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase. PLOS ONE 2014, 9: e101294. PMID: 25003500, PMCID: PMC4086815, DOI: 10.1371/journal.pone.0101294.Peer-Reviewed Original ResearchConceptsSpindle pole bodyKinetochore proteinsKinetochore componentsLate anaphaseYeast kinetochore proteinsCentromere/kinetochoreMicrotubule-dependent forcesKinetochore microtubule dynamicsProtein-protein interactionsKinetochore-microtubule interactionsWild-type cellsPolar ejection forcesCtf19 complexFunctional kinetochoreProtein complexesPole bodyMutant cellsKinetochoresCentromeresComplex membersMicrotubule dynamicsCell cycleCtf19pRescue frequencyPhysical interaction
2013
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips
Gudimchuk N, Vitre B, Kim Y, Kiyatkin A, Cleveland DW, Ataullakhanov FI, Grishchuk EL. Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nature Cell Biology 2013, 15: 1079-1088. PMID: 23955301, PMCID: PMC3919686, DOI: 10.1038/ncb2831.Peer-Reviewed Original ResearchConceptsDynamic microtubule endsMicrotubule endsMicrotubule tipsKinetochore kinesin CENPCENP-E motorDynamic microtubule tipsSingle-molecule approachVertebrate mitosisSpindle microtubulesTail domainCENPStable associationKinetochoresPlus endsChromosomesMolecular frameworkCentromeresMitosisMicrotubulesTransportersMotor mechanismsStability of attachmentVitroActive roleComputational modelling
2010
SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes
Neafsey D, Lawniczak M, Park D, Redmond S, Coulibaly M, Traoré S, Sagnon N, Costantini C, Johnson C, Wiegand R, Collins F, Lander E, Wirth D, Kafatos F, Besansky N, Christophides G, Muskavitch M. SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes. Science 2010, 330: 514-517. PMID: 20966254, PMCID: PMC4811326, DOI: 10.1126/science.1193036.Peer-Reviewed Original ResearchConceptsGenomic differentiationGenome-wide monitoringGreater genetic divergenceVector mosquito populationsMalaria vector mosquitoesAfrican malaria vector mosquitoesReproductive isolationBehavioral diversificationGenetic divergenceGenomic regionsNatural selectionPopulation structurePolymorphic inversionsSelective eventsSNP genotypingVector control effortsMosquito populationsVector mosquitoesDifferentiationComplex showDivergenceMosquitoesCentromeresGenomeSpecies
2001
Cryptic Translocation Identification in Human and Mouse Using Several Telomeric Multiplex FISH (TM-FISH) Strategies
Henegariu O, Artan S, Greally J, Chen X, Korenberg J, Vance G, Stubbs L, Bray-Ward P, Ward D. Cryptic Translocation Identification in Human and Mouse Using Several Telomeric Multiplex FISH (TM-FISH) Strategies. Laboratory Investigation 2001, 81: 483-491. PMID: 11304567, DOI: 10.1038/labinvest.3780256.Peer-Reviewed Original ResearchConceptsSubtelomeric regionsHuman subtelomeric regionsMouse chromosomesHuman chromosomesP1 clonesMouse probeMultiplex fluorescenceM-FISHChromosomesFISH strategySet of probesStandard fluorescence microscopeSmall rearrangementsSitu hybridizationLabeling strategyCryptic translocationSubtelomeric probesIdiopathic mental retardationFluorescence microscopeKnown markerCentromeresKilobases
1997
A case with mosaic di‐, tetra‐, and octacentric ring Y chromosomes
Henegariu O, Pescovitz O, Vance G, Verbrugge J, Heerema N. A case with mosaic di‐, tetra‐, and octacentric ring Y chromosomes. American Journal Of Medical Genetics 1997, 71: 426-429. PMID: 9286449, DOI: 10.1002/(sici)1096-8628(19970905)71:4<426::aid-ajmg10>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsPresence of heterochromatinHigh-resolution G-bandingSpecific banding patternsHuman telomeresSRY locusRing Y chromosomeY chromosomePaint probesY centromereColor FISHBanding patternsPCR analysisUllrich-Turner syndromeTriple-color FISHQ-bandingRing chromosomesG-bandingChromosomesPhallic structuresUrogenital openingFishCentromeresHeterochromatinTelomeresLoci
1993
Physical and Genetic Maps for Chromosome 10
Lichter J, Difilippantonio M, Pakstis A, Goodfellow P, Ward D, Kidd K. Physical and Genetic Maps for Chromosome 10. Genomics 1993, 16: 320-324. PMID: 8314570, DOI: 10.1006/geno.1993.1192.Peer-Reviewed Original ResearchConceptsChromosome 10Physical mapOrder of lociGenetic mapLinkage mapGenetic distanceFemale mapGenetic linkage studiesMetaphase chromosomesPolymorphic lociNew lociQ armLociFractional lengthCentromeresLinkage studiesFishPhysical distanceRecombinationCentimorgansChromosomesDistance estimatesFemalesMalesFluorescence
1992
Regional localization of the selenocysteine tRNA gene (TRSP) on human chromosome 19
Mitchell A, Bale A, Lee B, Hatfield D, Harley H, Rundle S, Fan Y, Fukushima Y, Shows T, McBride O. Regional localization of the selenocysteine tRNA gene (TRSP) on human chromosome 19. Cytogenetic And Genome Research 1992, 61: 117-120. PMID: 1395717, DOI: 10.1159/000133385.Peer-Reviewed Original Research
1990
Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region
Wu J, Kidd K. Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region. Human Genetics 1990, 84: 279-282. PMID: 1968036, DOI: 10.1007/bf00200575.Peer-Reviewed Original ResearchConceptsAlpha satellite DNAExtensive sequence polymorphismSatellite DNAPericentromeric regionSequence polymorphismsExcellent genetic markerCentromeric regionsDNA markersGenetic markersEnzyme PstILOD scoreClose linkagePositive lod scoresLinkage studiesDNAType 2AIndependent supportPolymorphismCentromeresMorphsMarkersRBP3LociDistance relationshipsEcoRV
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