Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
Nithianandam V, Sarkar S, Feany M. Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency. Human Molecular Genetics 2024, 33: 860-871. PMID: 38324746, PMCID: PMC11070137, DOI: 10.1093/hmg/ddae018.Peer-Reviewed Original ResearchConceptsComplex I deficiencyI deficiencyElectron transport chain componentsMitochondrial complex I deficiencyMitochondrial respiratory chainProteostasis failureMitochondrial genesProteostasis machineryDrosophila retinaProteostasis dysfunctionGenetic screeningProteostasisRespiratory chainAge-related neurodegenerationProtein degradationMitochondrial encephalomyopathyComplex IKinome screenGenetic modelsChain componentsNeurodegenerationProteinPathwayOxidative stressDrosophila
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