2013
Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation
Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 2013, 141: 281-295. PMID: 24335256, PMCID: PMC3879810, DOI: 10.1242/dev.093690.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell LineageCell ProliferationEmbryonic Stem CellsFemaleHeartHeart Defects, CongenitalIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, KnockoutMice, TransgenicMorphogenesisMyocardiumMyocytes, CardiacNerve Tissue ProteinsPregnancyReceptor, Notch1Signal TransductionConceptsNumb family proteinsCardiac progenitor differentiationCardiac progenitor cell differentiationSecond heart fieldProgenitor differentiationCardiac morphogenesisEndocytosis-dependent mannerProgenitor cell differentiationFamily proteinsCell differentiationOFT alignmentMultiple progenitor cell typesCell fate determinantsLate cardiac developmentEarly embryonic lethalityMRNA deep sequencingProgenitor cell typesSuppression of Notch1Fate determinantsNotch1 intracellular domainEmbryonic lethalEmbryonic lethalityReporter linesDifferentiation defectsHeart field
2008
Timing cell-fate determination during asymmetric cell divisions
Zhong W. Timing cell-fate determination during asymmetric cell divisions. Current Opinion In Neurobiology 2008, 18: 472-478. PMID: 18983918, PMCID: PMC2609754, DOI: 10.1016/j.conb.2008.10.005.Peer-Reviewed Original ResearchConceptsAsymmetric cell divisionCell divisionCell cycle progressionFate determinantsCell fate determinantsCell fate determinationCell fateDaughter cellsCellular organellesMolecular mechanismsCell cycleGolgi apparatusIntracellular signalingSubcellular distributionDifferent fatesCell typesNovel mechanismCell proliferationMolecular compositionMultiple roundsRecent findingsDivisionFateInvertebratesCentrosomesInstructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors
Ghosh S, Marquardt T, Thaler JP, Carter N, Andrews SE, Pfaff SL, Hunter T. Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 335-340. PMID: 18162555, PMCID: PMC2224213, DOI: 10.1073/pnas.0705713105.Peer-Reviewed Original ResearchConceptsAdherens junctionsNeural progenitorsNeural tubeApical-basal polarityCell fate determinantsNeuronal precursorsApical adherens junctionsApical membranePKCzeta/lambdaCell-cell adhesionChicken neural tubeStem cell proliferationPostmitotic neuronal precursorsAsymmetric inheritanceApical assemblyFate determinantsAsymmetric localizationNeural stem cell proliferationSubcellular compartmentalizationSubcellular localizationNeural stem cellsKinase activityInstructive signalsNeurogenic divisionsInstructive role
1997
Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast
Takizawa P, Sil A, Swedlow J, Herskowitz I, Vale R. Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature 1997, 389: 90-93. PMID: 9288973, DOI: 10.1038/38015.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnaphaseBase SequenceBiological TransportCell DivisionCytoskeletonDNA-Binding ProteinsFungal ProteinsGene DeletionIn Situ Hybridization, FluorescenceMicroscopy, FluorescenceRepressor ProteinsRNA, FungalRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsConceptsCell fate determinantsASH1 mRNACell fateDaughter budsActin cytoskeletonMating-type switchingMother-bud neckActin-dependent localizationMulticellular eukaryotesHigher eukaryotesRNA localizationCell cortexMRNA particlesCytoplasmic localizationAsymmetric distributionUntranslated regionActin filamentsMessenger RNADistal tipEukaryotesCytoskeletonMRNAYeastRNADaughter nuclei
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