2025
Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice
Macêdo A, de Sousa Neto I, Antonio G, Gaspar R, de Lima R, Dias L, Vieira R, Muñoz V, Brunelli D, da Silva A, Cintra D, Ropelle E, Pauli J. Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice. Nutrition 2025, 133: 112691. PMID: 39983606, DOI: 10.1016/j.nut.2025.112691.Peer-Reviewed Original ResearchConceptsRNA-seq datasetsNotch1 intracellular domainMitochondrial respirationTime-restricted feedingAged miceInflammatory markersAd libitum dietIntracellular domainHepatic mitochondrial respirationATP productionLiver mitochondrial respirationCellular longevityLiver of aged miceLibitum dietDisease Activity ScoreCompared to adult animalsNotch1 signalingProtein contentTime-restricted feeding protocolsUpregulation of Notch1Investigated metabolic parametersProtein levelsNotch1Adult miceCollagen fibers
2013
Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation
Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 2013, 141: 281-295. PMID: 24335256, PMCID: PMC3879810, DOI: 10.1242/dev.093690.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell LineageCell ProliferationEmbryonic Stem CellsFemaleHeartHeart Defects, CongenitalIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, KnockoutMice, TransgenicMorphogenesisMyocardiumMyocytes, CardiacNerve Tissue ProteinsPregnancyReceptor, Notch1Signal TransductionConceptsNumb family proteinsCardiac progenitor differentiationCardiac progenitor cell differentiationSecond heart fieldProgenitor differentiationCardiac morphogenesisEndocytosis-dependent mannerProgenitor cell differentiationFamily proteinsCell differentiationOFT alignmentMultiple progenitor cell typesCell fate determinantsLate cardiac developmentEarly embryonic lethalityMRNA deep sequencingProgenitor cell typesSuppression of Notch1Fate determinantsNotch1 intracellular domainEmbryonic lethalEmbryonic lethalityReporter linesDifferentiation defectsHeart field
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