Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis.
Hoos A, Nissan A, Stojadinovic A, Shia J, Hedvat C, Leung D, Paty P, Klimstra D, Cordon-Cardo C, Wong W. Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis. Clinical Cancer Research 2002, 8: 3841-9. PMID: 12473598.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCell Cycle ProteinsCyclin D1Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27CyclinsDisease-Free SurvivalFemaleHumansImmunoenzyme TechniquesKi-67 AntigenMaleMiddle AgedNeoplasm ProteinsNuclear ProteinsProtein Array AnalysisProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Rectal NeoplasmsTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsDisease-specific survivalNode-negative adenocarcinomaTreated by surgeryCell cycle-regulatoryDown-regulation of p27Reduced DFSTumor suppressor genes associated with developmentMolecular profilingFavorable overall prognosisHomogeneous group of patientsDied of diseaseAssociated with recurrenceStages of colorectal cancerTumor-related mortalityDevelopment of metastasesAggressive biological behaviorGroup of patientsEarly-stage adenocarcinomaExpression of p53Cyclin-dependent kinase inhibitorDown-regulationProliferation-related markersCurative intentMetastatic diseasePrimary tumor
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