2024
Flow cytometry-assisted analysis of phenotypic maturation markers on an immortalized dendritic cell line
Campia G, Beltrán-Visiedo M, Soler-Agesta R, Sato A, Bloy N, Zhao L, Liu P, Kepp O, Kroemer G, Galluzzi L, Galassi C. Flow cytometry-assisted analysis of phenotypic maturation markers on an immortalized dendritic cell line. Methods In Cell Biology 2024, 189: 153-168. PMID: 39393881, DOI: 10.1016/bs.mcb.2024.05.008.Peer-Reviewed Original ResearchCD8+ cytotoxic T lymphocytesDendritic cellsCross-PresentationMHC class I molecules to CD8Tumor-derived materialBone marrow-derived precursorsCytotoxic T lymphocytesImmuno-oncology studiesMHC class II moleculesFresh dendritic cellsIn vitroMarrow-derived precursorsClass II moleculesDendritic cell lineAnticancer immunityDC activationActivation markersDC functionT lymphocytesMaturation markersTerminally differentiated cellsScreening programII moleculesI-DCsCell lines
2017
Dynamic modulation of cortical actin at the immunological synapse controls lytic granule secretion in cytotoxic T lymphocytes
Kapnick S, Ritter A, Griffiths G, Lippincott-Schwartz J, Schwartzberg P. Dynamic modulation of cortical actin at the immunological synapse controls lytic granule secretion in cytotoxic T lymphocytes. The Journal Of Immunology 2017, 198: 151.4-151.4. DOI: 10.4049/jimmunol.198.supp.151.4.Peer-Reviewed Original ResearchCortical actinLytic granule secretionGranule fusionGranule secretionRecovery of actinActin regulatory proteinsClearance of actinActin recoveryActin cytoskeletonCD8+ cytotoxic T lymphocytesPolarized secretionRegulatory proteinsKill multiple targetsTIRF microscopyFluorescent reportersLytic proteinsActinImmunological synapseRAB27A mutationsSpecialized granulesSecretion granulesInfected cellsKill cellsVirally infected cellsCytotoxic T lymphocytes
1995
Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway
Isaaz S, Baetz K, Olsen K, Podack E, Griffiths G. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway. European Journal Of Immunology 1995, 25: 1071-1079. PMID: 7737276, DOI: 10.1002/eji.1830250432.Peer-Reviewed Original ResearchConceptsCD8+ cytotoxic T lymphocytesLytic proteinsBrefeldin ALytic granulesConstitutive secretory pathwayCytotoxic T lymphocytesGranzyme ABystander killingSecretory pathwayNatural killer cell lineGranzyme BT lymphocytesConstitutive pathwayCD8+ cytotoxic T lymphocyte clonesConstitutive secretionTCR cross-linkingLytic pathwaySecretory granulesAllogeneic target cellsT cell receptorTarget signalTCR triggeringProteinTarget cell recognitionCell lines
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