Dynamic modulation of cortical actin at the immunological synapse controls lytic granule secretion in cytotoxic T lymphocytes
Kapnick S, Ritter A, Griffiths G, Lippincott-Schwartz J, Schwartzberg P. Dynamic modulation of cortical actin at the immunological synapse controls lytic granule secretion in cytotoxic T lymphocytes. The Journal Of Immunology 2017, 198: 151.4-151.4. DOI: 10.4049/jimmunol.198.supp.151.4.Peer-Reviewed Original ResearchCortical actinLytic granule secretionGranule fusionGranule secretionRecovery of actinActin regulatory proteinsClearance of actinActin recoveryActin cytoskeletonCD8+ cytotoxic T lymphocytesPolarized secretionRegulatory proteinsKill multiple targetsTIRF microscopyFluorescent reportersLytic proteinsActinImmunological synapseRAB27A mutationsSpecialized granulesSecretion granulesInfected cellsKill cellsVirally infected cellsCytotoxic T lymphocytes
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