Inherited Variants in the Chemokine CCL2 Gene and Prostate Cancer Aggressiveness in a Caucasian Cohort
Sun T, Mary L, Oh W, Freedman M, Pomerantz M, Pienta K, Kantoff P. Inherited Variants in the Chemokine CCL2 Gene and Prostate Cancer Aggressiveness in a Caucasian Cohort. Clinical Cancer Research 2011, 17: 1546-1552. PMID: 21135144, PMCID: PMC3060307, DOI: 10.1158/1078-0432.ccr-10-2015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAllelesChemokine CCL2Cohort StudiesDisease ProgressionGenetic Predisposition to DiseaseGenetic VariationGenotypeHaplotypesHumansLinkage DisequilibriumMaleMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisPolymorphism, Single NucleotideProstatectomyProstatic NeoplasmsRiskConceptsC-C chemokine ligand 2Prostate cancer aggressivenessSingle nucleotide polymorphismsCancer aggressivenessMarkers of disease aggressivenessAssociated with advanced pathological stageBiopsy Gleason scoreGood-risk featuresProstate cancer developmentProstate cancer progressionAdvanced pathological stageChemokine ligand 2Associated with markersProstate cancer tumorigenesisGleason scoreRadical prostatectomyClinicopathological variablesPathological stageDisease aggressivenessPatient cohortG alleleGermline variantsCaucasian cohortProstateRisk features
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